Results 131 to 140 of about 472,711 (314)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme

BMC Medicine
Background People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time.
Anthony Martyr, Laura D. Gamble, Anna Hunt, Catherine Quinn, Robin G. Morris, Catherine Henderson, Louise Allan, Carol Opdebeeck, Catherine Charlwood, Roy W. Jones, Claire Pentecost, Michael D. Kopelman, Jeanette M. Thom, Fiona E. Matthews, Linda Clare   +14 more
doaj   +1 more source

Reliability and validity of the geriatric depression scale in Italian subjects with Parkinson's disease [PDF]

, 2018
Introduction. The Geriatric Depression Scale (GDS) is commonly used to assess depressive symptoms, but its psychometric properties have never been examined in Italian people with Parkinson's disease (PD).
Colalelli, Francesca, Fabbrini, Andrea, Fabbrini, Giovanni, Galeoto, Giovanni, Massai, Perla, Sansoni, Julita, Scuccimarri, Michela, Tofani, Marco, Valente, Donatella   +8 more
core   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Dementia and functional decline in patients with Parkinson's disease

Dementia & Neuropsychologia
Functional decline in Parkinson's disease (PD), characterized by reduced ability to carry out activities of daily living, usually results from typical motor impairment and may be aggravated by concomitant cognitive impairment.
Florindo Stella, Claudio Eduardo Muller Banzato, Elizabeth Maria Aparecida Barasnevicius Quagliato, Maura Aparecida Viana, Gustavo Christofoletti   +4 more
doaj   +1 more source

11C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia

Annals of Clinical and Translational Neurology, 2019
There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as 11C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated ...
Nicolas Nicastro, Ajenthan Surendranathan, Elijah Mak, James B. Rowe, John T. O’Brien   +4 more
doaj   +1 more source

ICF-Based Disability Survey in a Rural Population of Adults and Older Adults Living in Cinco Villas, Northeastern Spain: Design, Methods and Population Characteristics [PDF]

, 2010
Background: This article describes the methods of a door-to-door screening survey exploring the distribution of disability and its major determinants in northeastern Spain.
Alberto Larrosa, Luis, Alcalde Cabero, Enrique, Almazan Isla, Javier, Avellanal, Fuencisla, Burzaco, Olga, Cieza, Alarcos, Comin Comin, Magdalena, Damian, Javier, de Pedro-Cuesta, Jesus, Frades, Belen, Franco, Esther, Joao Forjaz, Maria, Magallon, Rosa, Manuel Castellote, Juan, Martin Garcia, Gloria, Martinez Martin, Pablo, Martinez, Cristina, Pastor-Barriuso, Roberto, Pena Jimenez, Ana, Poblacion Martinez, Adolfo, Reed, Geoffrey, Ruiz, Cristina, Virues-Ortega, Javier   +22 more
core   +1 more source

Meta-analysis of risk factors for Parkinson’s disease dementia

Translational Neurodegeneration, 2016
BackgroundParkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder population. Parkinson’s disease dementia (PDD) is one of the most common non-motor manifestations in PD patients.
Yaqian Xu, Jing Yang, H. Shang
semanticscholar   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Effect Differences of Omega‐3 Fatty Acids From Plant Oil and Fish Oil on Human Health

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Omega‐3 fatty acids in plant oil is no less than fish oil on human health. ALA in plant oil takes directly healthy effects without conversion to DHA and EPA. Plant oil can be substitutes for fish oil to support partial ω‐3 fatty acids. For people who cannot afford fish oil, plant oil is also good for public health.
Mengxue Fang, Chunyan Xiang, Liangxiao Zhang, Peiwu Li   +3 more
wiley   +1 more source