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Pain in atypical parkinsonism, vascular parkinsonism, and Parkinson’s disease
Neurological Sciences, 2022Pain is a common symptom in Parkinson's disease (PD) and is considered a pre-motor symptom suggesting sensory involvement in the pre-motor stage. Pain in other parkinsonian disorders such as atypical parkinsonism and vascular parkinsonism (VP) has been investigated in only a few studies.
Young Hee Sung, Suk Yun Kang
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Seminars in Neurology, 2016
Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (
Adrienne M, Keener, Yvette M, Bordelon
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Parkinsonism is a clinical syndrome, which is characterized by bradykinesia, rigidity, rest tremor, and postural instability. Idiopathic Parkinson disease (PD) is the most common cause of this syndrome, though there are several other important etiologies that must be considered. These include the atypical Parkinsonian disorders multiple system atrophy (
Adrienne M, Keener, Yvette M, Bordelon
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Parkinson's Disease and Parkinsonism
The American Journal of Medicine, 2019Parkinson's disease is a progressive neurodegenerative disease characterized by tremor and bradykinesia and is a common neurologic ailment. Male sex and advancing age are independent risk factors and, as the population ages, is taking an increasing toll on productivity and medical resources.
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Genetics of Parkinson's disease and parkinsonism
Annals of Neurology, 2006AbstractUntil 10 years ago, conventional wisdom held that Parkinson's disease was not a genetic disorder. Since that time, there have been a plethora of genetic findings, culminating in the cloning of several genes that derive from the loci given the nomenclature PARK1‐PARK12 (OMIM 168600).
John, Hardy +4 more
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Genetics of Parkinson’s disease and parkinsonism
Expert Review of Neurotherapeutics, 2007The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased ...
Michael R, Douglas +2 more
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Identification of parkinsonism and Parkinson's disease
Drugs of Today, 2002Parkinson's disease is a common movement disorder associated with considerable disability. The clinical syndrome of parkinsonism is based on the presence of core clinical features of rest tremor, bradykinesia, rigidity and impaired postural reflexes or gait.
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James Parkinson: Parkinson's Disease
Journal of Perioperative Practice, 2013Parkinson's disease is a condition that anyone with a modicum of medical knowledge can recognise in the street - as indeed how it was studied by James Parkinson himself. Its three characteristic features are: 1. Increase in the tone of the voluntary muscles (rigidity). 2. Slowness of movement (bradykinesis).
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Sphingolipids in the Pathogenesis of Parkinson’s Disease and Parkinsonism
Trends in Endocrinology & Metabolism, 2019The pathogenic mechanisms underlying Parkinson's disease (PD)/parkinsonism affect mitochondrial and endolysosomal trafficking. The retromer is required to retrieve some proteins from endosomes to the Golgi and plasma membrane. Here, we discuss how retromer-dependent retrieval also affects ceramide metabolism.
Guang, Lin +3 more
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