Results 201 to 210 of about 223,878 (259)

Gait Analysis for Identifying Normal Cognition, Subjective Cognitive Decline, and Mild Cognitive Impairment in Parkinson Disease: Diagnostic Study. [PDF]

JMIR Mhealth Uhealth
Huang J, Wu L, Wang H, Chen L, Hu B, Zhang F, Ren K, Ling Y, Chen Z, Huang W.   +9 more
europepmc   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Demographic Confounding in Voice-Based Parkinson Disease Screening: Methodological Analysis of the Bridge2AI Voice Dataset. [PDF]

J Med Internet Res
Shukla S, Naliyatthaliyazchayil P, Gichoya JW, Purkayastha S.   +3 more
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Common MC1R Variants and Parkinson Disease Progression.

JAMA Neurol
Schumacher JG, Zhang X, Wang J, Dijkstra JM, Watanabe H, Gao X, Cortese M, Macklin EA, Schwarzschild MA, Chen X.   +9 more
europepmc   +1 more source

Continuous subcutaneous levodopa and foslevodopa infusion therapy for motor symptoms of Parkinson disease: A systematic review of observational studies. [PDF]

Medicine (Baltimore)
Ali A, Cheema WA, Shamoon M, Azam H, Yousuf D, Tanveer A, Asif W, Nisar F, Ghafoor LA, Talha M, Ali MA, Saleem U, Shabbir MA, Abdullah A, Sharma M.   +14 more
europepmc   +1 more source

Cost‐Effective Ti/Al/Ni Multilayer Neural Probes With In Vivo Recording Performance Comparable to Ti/Au Neural Probes

Advanced Electronic Materials, EarlyView.
In this study, we developed a cost‐efficient neural probe by replacing traditional gold with an aluminum‐based Ti/Al/Ni multilayer stack. Optimizing this metal architecture suppressed oxidation and ensured robust electrical stability, achieving signal quality comparable to standard gold probes. It enables a highly accessible and economical solution for
Sehwan Park, Minseok Kim, Giheon Kim, Seungjun Lee, Haeyun Lee, Namsun Chou, Hyogeun Shin   +6 more
wiley   +1 more source

In Tribute: Farshid Mohammadi, PT, PhD, Proprioception and Sensorimotor Integration in Parkinson’s Disease

Physical Treatments, 2014
Mahyar Salavati, Behnam Akhbari
doaj  

Optimal exercise modalities and dosages for improving depression in middle-aged and older adults with Parkinson's disease: A Bayesian Dose-response network meta-analysis. [PDF]

PLoS One
Lyu Y, Chen J, Zeng S.
europepmc   +1 more source