Results 191 to 200 of about 223,878 (259)

Use of receptor and nonreceptor tyrosine kinase inhibitors and Parkinson disease risk. [PDF]

open access: yesNeurotherapeutics
Malaty GR   +4 more
europepmc   +1 more source

Sydney Parkinson [picture] /

open access: yes
Frontispiece to: Journal of a voyage to the South Seas / Sydney Parkinson.; Beddie, 4612.; Exhibited: Treasures Gallery NLA: Portraits of the Famous and Infamous, August 2015 – December 2015; Rex Nan Kivell Collection NK1323 ...
Newton, James, 1748-approximately 1804.
core  

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

open access: yesAdvanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu   +12 more
wiley   +1 more source

Systematic review of Parkinson's disease investigated using electroencephalographic technique and linear and nonlinear signal analysis methods.

open access: yes
openIl morbo di Parkinson è una malattia neurodegenerativa complessa che richiede tecniche avanzate per il suo studio e diagnosi. Questa tesi si focalizza sull'utilizzo di tecniche lineari e non lineari per l'analisi dei segnali Elettroencefalografici ...
PEZZOTTINI, AMBRA
core  

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

open access: yesAdvanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir   +3 more
wiley   +1 more source

Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO

open access: yesAdvanced Science, EarlyView.
AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu   +9 more
wiley   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

open access: yesAdvanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman   +11 more
wiley   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

open access: yesAdvanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou   +3 more
wiley   +1 more source

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