Results 231 to 240 of about 442,406 (307)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

Effects of virtual reality intervention dosage on gait performance in Parkinson's disease: a systematic review and meta-analysis. [PDF]

PeerJ
Yu S, Zhu Y, Yang Y.
europepmc   +1 more source

Skin‐Conformal Myography for Real‐Time Hand Tracking Using a Laser‐Induced Graphene Strain Sensor Array

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A skin‐conformal wearable device based on laser‐induced graphene is developed for continuous strain measurement across the circumference of the forearm for gesture recognition and hand‐tracking applications. Post material optimization, the strain sensor array is integrated with a wearable wireless readout circuit for real‐time control of a robotic arm,
Vinay Kammarchedu, Monther AlSiyabi, Aida Ebrahimi   +2 more
wiley   +1 more source

Wearable Metamaterials with Embodied Intelligence for Programmable Control of Human Limbs Tremor

Advanced Intelligent Systems, EarlyView.
Resulting from alternating muscle contractions, tremors can severely limit human ability to perform everyday tasks like walking or talking, due to their disruptive nature. Medication and surgery may not always effectively address tremor control. A wearable device embodying programmable smart metamaterials with adaptable intelligence to meet the demand ...
Braion Barbosa de Moura, Marcela R. Machado, Tanmoy Mukhopadhyay   +2 more
wiley   +1 more source

Laparoscopic Cholecystectomy in a Young Female With Wolff-Parkinson-White Syndrome: Anesthetic Implications and Case Report. [PDF]

Clin Case Rep
Bhatta S, Pandit S.
europepmc   +1 more source

Author Correction: Proceedings of the world summit on parkinson's disease. [PDF]

NPJ Parkinsons Dis
Mantri S, Ghilardi MF, Lessard N, Norcini M, Di Rocco A, Wallock K, Lehr J, Okun MS, World Summit Steering Committee.   +8 more
europepmc   +1 more source

Lower Urinary Tract Symptoms Correlation With Motor and Cognitive Function in Patients With Parkinson Disease. [PDF]

Int Neurourol J
Golesorkhi N, Leta V, Chaudhuri KR, Walker NAF.   +3 more
europepmc   +1 more source

Autologous Peripheral Nerve Tissue Grafts Implanted into the Nucleus Basalis of Meynert and Substantia Nigra at the Time of Bilateral Deep Brain Stimulation in Parkinson Disease: A Report of 2 Cases. [PDF]

Neurosurg Pract
Daly SR, Quintero JE, Koehl L, Wallace E, Guduru Z, Gurwell JA, Hines T, Hixson J, Hulou S, Slevin JT, Schmitt FA, Gerhardt GA, van Horne CG.   +12 more
europepmc   +1 more source