Results 171 to 180 of about 98,362 (265)

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

Use and misuse of domperidone in patients living with Parkinson disease in France. [PDF]

Fundam Clin Pharmacol
Januel E, Corvol JC, Remy P, Meissner WG, Thiriez C, Lanore A, Bonnet C, Azulay JP, Giordana C, Maltete D, Frismand S, Tranchant C, Sellal F, Jager A, Béreau M, Castelnovo G, Vallet AE, Lapeyre-Mestre M, Turc JD, Rascol O, Tubach F, DUMP study group.   +21 more
europepmc   +1 more source

A Versatile Near‐Infrared Fluorescent Probe for Fast Assessment of Lysosomal Status via a Large Multimodal Model

Aggregate, EarlyView.
Herein, we report a quinolinium‐based fluorescent probe, PA‐2, for near‐infrared super‐resolution imaging of lysosomal dynamics. Building on this, we next introduce a novel approach leveraging a large multimodal model (LMM), an advanced artificial intelligence tool, for automated image interpretation.
Rui Chen, Eugene Lee, Yuxin Wang, Aditya Yadav, Minling Zhong, Pragti, Yujie Sun, Jiajie Diao   +7 more
wiley   +1 more source

Correction to: The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease. [PDF]

Hum Mol Genet
europepmc   +1 more source

Psychometric properties of the Italian version of scale for outcomes in Parkinson's disease psychiatric complications in Parkinson disease. [PDF]

Sci Rep
Cuoco S, Cappiello A, Carotenuto I, Autuori M, Bisogno R, Sorrentino C, Aiello M, Barone P, Picillo M.   +8 more
europepmc   +1 more source

Supramolecular Probe for Monitoring Lysosomal Ferritinophagy to Facilitate the Early Diagnosis of Parkinson's Disease

Aggregate, EarlyView.
A supramolecular fluorescent probe, TPE‐4B/4Q[7], was designed to target lysosomes. The restriction of intramolecular rotation effect mediated by Q[7] enhances the fluorescence of TPE‐4B/4Q[7], enabling selective detection of Fe3+ with a detection limit of 1.23 × 10⁻⁶ M.
Shiqin Zhou, Bo Xiao, Jiamin Chen, Jinming Zhu, Xia Ran, Zuoji Liu, Chaozhong Li, Li Wang, Xinai Cui, Rong Li, Guangwei Feng, Jian Feng   +11 more
wiley   +1 more source

Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease: Drug-Wide Trial Emulation. [PDF]

Neurology
Tuominen JA, Riise T, Romanowska J, Flores-Torres MH, Cortese M, Scherzer CR, Bjornevik K, Igland J.   +7 more
europepmc   +1 more source

Illuminating Tau Aggregates: Multiscale Approaches for Detection, Imaging, and Understanding

Aggregate, EarlyView.
This review presents recent advances in molecular imaging of tauopathies, focusing on tau aggregation mechanisms, structural polymorphism, and imaging strategies. It highlights the development of tau‐selective fluorescent probes and PET tracers and explores emerging techniques such as cryo‐EM and super‐resolution imaging, offering a multiscale ...
Kaustubh R. Bhuskute, Jiayi Fan, Amandeep Kaur   +2 more
wiley   +1 more source

Piezoelectric Origami Metamaterials for Enhanced Handwriting Recognition and Trajectory Tracking

Advanced Intelligent Discovery, EarlyView.
This study introduces origami metamaterials inspired by Kresling piezoelectric generators to enhance biometric authentication and handwriting trajectory recognition. Overcoming sensor limitations in conventional devices, the design enables multichannel data acquisition with fewer sensors, utilizing machine learning to accurately identify content ...
Yinzhi Jin, Ting Tan, Zhimiao Yan
wiley   +1 more source