Results 191 to 200 of about 128,160 (300)

Clinician Communication About Uncertainty During Parkinson Disease Diagnostic Consultations. [PDF]

Neurol Clin Pract
Hillen MA, Kurpershoek E, Huisman MHB, Pleizier CM, Vlaar A, Blankevoort J, Zoons E, Roos DS, de Visser M, de Bie RMA, Dijk JM.   +10 more
europepmc   +1 more source

Validation of Parkinson Cognitive Examination (PaCE) for early diagnosis of cognitive impairment in Parkinson's Disease

reservedL’obiettivo del presente studio riguarda la validazione di un nuovo strumento di valutazione neuropsicologica: il Parkinson’s disease Cognitive Examination (PaCE), progettato per rilevare con maggiore accuratezza i primi segnali di compromissione
RASI, GAIA
core  

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Exposure to Air Pollutants and Lewy Body and Parkinson Disease-Related Dementias.

JAMA Netw Open
Davydow DS, Pontone GM, Okun MS, Armstrong MJ, Böttger TW, Geels C, Frohn LM, Brandt J, Dreier JW, Christensen J, Pedersen CB, Horsdal HT.   +11 more
europepmc   +1 more source

Association of the Naples prognostic score with Parkinson disease risk: a prospective cohort study. [PDF]

Front Aging Neurosci
Xu Z, Wang X, Yang G, Li N.
europepmc   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial.

JAMA Neurol
Pahwa R, Moro E, Espay AJ, Evans A, Saint-Hilaire M, Torres-Russotto D, Sanchez R, Leoni M, Duvvuri S, Combs C, Chang I, Tringali S, Boiser J, Zadikoff C, Antonini A.   +14 more
europepmc   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Case Definitions and Data Sources for NNCSS Parkinson Disease Surveillance: A Systematic Review.

JAMA Netw Open
Esper CD, Hogan KN, Abeysekara P, Smith KN, Smith TG, Mercer SL.   +5 more
europepmc   +1 more source

Multimodal Intelligent Monitoring of Parkinson Disease: Scoping Review of Progress and Translational Challenges. [PDF]

J Med Internet Res
Tan J, Deng X, Wu C, Yao M, Liao J, Zheng H, Lian C.   +6 more
europepmc   +1 more source