Results 211 to 220 of about 128,160 (300)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Investigating the Genetic Relationship Between Vitamin B12 Metabolism and Parkinson Disease. [PDF]

Neurol Genet
Dering R, Onvumere M, Liu L, Huot P, Gan-Or Z, Senkevich K.   +5 more
europepmc   +1 more source

Parkinson's disease [PDF]

Nature, 2010
openaire   +3 more sources

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

The influence of visual input and attention on gait initiation in people with Parkinson disease. [PDF]

PLoS One
Duppen CP, Surkin J, Mahendar S, Saunders J, Cole J, Browner N, Lewek MD.   +6 more
europepmc   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

Parkinson Disease Mortality Among Adults Age 65 and Older: United States, 2024.

NCHS Data Brief
Kramarow EA, Escobedo LA, Tejada-Vera B.
europepmc   +1 more source

Examining Sensory Systems That Contribute to Falls in Parkinson Disease Using Computerized Dynamic Posturography: Secondary Analysis. [PDF]

JMIR Form Res
Rivera M.
europepmc   +1 more source

Skin‐Conformal Myography for Real‐Time Hand Tracking Using a Laser‐Induced Graphene Strain Sensor Array

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A skin‐conformal wearable device based on laser‐induced graphene is developed for continuous strain measurement across the circumference of the forearm for gesture recognition and hand‐tracking applications. Post material optimization, the strain sensor array is integrated with a wearable wireless readout circuit for real‐time control of a robotic arm,
Vinay Kammarchedu, Monther AlSiyabi, Aida Ebrahimi   +2 more
wiley   +1 more source

Intermittent Theta-Burst Stimulation for Depressive Symptoms in Parkinson Disease: A Randomized Clinical Trial.

JAMA Netw Open
Hou M, Tian B, Qi C, Song L, Ma B, Chen X, Wan Y, Wu N, Gan J, Liu Z, Zhang Y.   +10 more
europepmc   +1 more source