Results 71 to 80 of about 963,803 (317)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Analysis of national health accounts in Iran (2002–2020) [PDF]
PayeshObjective (s): Comprehensive data on health expenditures is crucial not only for effective policymaking but also for achieving universal health coverage and health-related sustainable development goals.
Abdoreza Mousavi +3 more
doaj
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
A Tale of Two Serbias? Census-taking in 2002 and 2011
Contemporary Southeastern Europe, 2015 The challenges implicit in census-taking are especially pronounced in the Western Balkans and, very specifically, in Serbia, considering this country’s multi-ethnic and multi-religious makeup, as reflected in territorial delineations, as well as its ...
Mina Djurić Nikolić, Laura Trimajova
doaj
FINANCING OF GROWTH IN AGRICULTURAL COOPERATIVES [PDF]
Sources and uses of funds in agricultural cooperatives are examined and compared to the aggregate of nonfinancial corporations for the period 1973-1987. Cooperatives are observed to finance nearly half their growth with equity.
Lerman, Zvi, Parliament, Claudia
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Conflict without an Apparent Cause
Games, 2019 A game-theoretic model of repeated interaction between two potential adversaries is analyzed to illustrate how conflict could possibly arise from rational decision-makers endogenously processing information, without any exogenous changes to the ...
Timothy Mathews, Aniruddha Bagchi
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source