Results 31 to 40 of about 25,024 (228)

Synthesis of Enantiopure trans-3,4-Disubstituted Piperidines. An Enantiodivergent Synthesis of (+)- and (−)-Paroxetine

, 2016
Reaction of (R)-phenylglycinol with methyl 5-oxopentanoate gave either bicyclic lactam cis-1 (the kinetic product) or its isomer trans-1 (under equilibrating conditions) as the major products, which were converted to the corresponding (cis or trans ...
Mercedes Amat (1763458), Modesto Orozco (10295), Maria Pérez (2673589), Elies Molins (1693357), Javier Luque (549740), Joan Bosch (129788), Carles Miravitlles (3049272), José Hidalgo (3033942), Margalida Cantó (3033021), Núria Llor (2485639)   +9 more
core   +2 more sources

Neuropharmacology of paroxetine

, 2003
Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI) with some neuropharmacologic properties unique among this class of compounds. The findings of early in vitro studies demonstrated the potency of paroxetine at inhibiting 5-HT uptake
Owens, Michael J, Nemeroff, Charles B
core   +4 more sources

Treatment of pruritus in a palliative care patient with low-dose paroxetine: a case report

Journal of Medical Case Reports, 2017
Background Pruritus is a distressing symptom seen in palliative care. There is limited high-quality evidence of pharmaceutical treatments for pruritus in palliative care, including the use of paroxetine.
Roni Y. Kraut
doaj   +1 more source

Anhydrides as Acylating Agents in the Enzymatic Resolution of an Intermediate of (−)-Paroxetine

, 2016
A new chemoenzymatic method for the preparation of an intermediate of (−)-Paroxetine is reported. Cyclic anhydrides are used as acylating agents in the lipase-catalyzed esterification of trans-4-(4‘-fluorophenyl)-3-hydroxymethyl-N ...
Gonzalo de Gonzalo (2310898), Rosario Brieva (3029382), Vicente Gotor (1566613), Miguel Bayod (3029379), Víctor M. Sánchez (3029385)   +4 more
core   +1 more source

The Different Roles of 5-HT2 and 5-HT3 Receptors on Antinociceptive Effect of Paroxetine in Chemical Stimuli in Mice

Journal of Pharmacological Sciences, 2005
Serotonin (5-HT) is known to be an important mediator in pain modulation. Some centrally acting agents, like selective serotonin reuptake inhibitors (SSRIs), modulate pain.
Murat Kesim, Erdem N. Duman, Mine Kadioglu, Ersin Yaris, Nuri I. Kalyoncu, Nesrin Erciyes   +5 more
doaj   +1 more source

Depression and/or PTSD Comorbidity Affects Response to Antidepressants in Those With Alcohol Use Disorder

Frontiers in Psychiatry, 2022
Objective: Depression and post-traumatic stress disorder (PTSD) highly co-occur with alcohol use disorder (AUD). The comparative effects of noradrenergic vs.
Peter J. Na, Peter J. Na, Elizabeth Ralevski, Elizabeth Ralevski, Oluwole Jegede, Aaron Wolfgang, Ismene L. Petrakis, Ismene L. Petrakis   +7 more
doaj   +1 more source

The role of harms and burdens in clinical practice guidelines: Lessons learned from the American Psychological Association's guideline development

Clinical Psychology: Science and Practice, EarlyView., 2020
Abstract Growing evidence supports the efficacy of various psychosocial interventions yet provides very little information about the potential harms and burdens of treatment. Lacking such information makes it difficult to make truly informed decisions about treatment options.
Raquel W. Halfond, Caroline Vaile Wright, Lynn F. Bufka   +2 more
wiley   +1 more source

Pd‐Catalyzed Asymmetric Dearomative Heck/Tsuji‐Trost Difunctionalization of Naphthalenes

Advanced Science, EarlyView.
We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Long‐Ling Ma, Bing Xu, Junliang Zhang, Zhan‐Ming Zhang   +3 more
wiley   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

Comparative Analysis between Controlled Release Paroxetine and Extended-Release Venlafaxine for Treatment of Depression

Journal of Nobel Medical College, 2022
Backgroud: Depression is a common condition seen in Psychiatry outpatient department. The treatment data suggest that the drugs that modulate the serotonergic neurotransmission are effective in the treatment of depression.
Vijay Kaul, Prithi Bahadur Rai
doaj   +1 more source