Results 71 to 80 of about 82,322 (154)

The pathophysiology of paroxysmal nocturnal hemoglobinuria and treatment with eculizumab

, 2009
Richard Kelly1, Stephen Richards1, Peter Hillmen1, Anita Hill21Institute of Oncology, St. James’s University Hospital, Leeds, UK; 2Department of Haematology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UKAbstract: Paroxysmal ...
Stephen Richards, Peter Hillmen, et al, Richard Kelly   +3 more
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Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria

Saudi Journal of Kidney Diseases and Transplantation, 2015
Paroxysmal nocturnal hemoglobinuria is a rare disease of the red blood cell membrane that renders it lyzable by the complement system, leading to chronic intravascular hemolysis. Renal hemosiderosis is a well-known complication of intravascular hemolytic
Deena T Boqari, Shatha Al Faraj, Maria Arafah, Nourah Aloudah, Khalid S Alkhairy, Ahmed Alsuhaibani, Khaled O Alsaad   +6 more
doaj   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Mechanisms of paroxysmal nocturnal hemoglobinuria clonal expansion [PDF]

, 2018
Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired clonal disease of bone marrow stem-cells, genetically characterized by the somatic mutation of the phosphatidylinositol glycan class A (PIG-A) gene.
Peixoto, Vanda, Vieira da Silva, Manuela, Prudêncio, Cristina   +2 more
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Evaluating the treatment of patients with paroxysmal nocturnal hemoglobinuria in Brazil: disparities in access and treatment persistence

Hematology, Transfusion and Cell Therapy
Background: Paroxysmal nocturnal hemoglobinuria is a rare, life-threatening disease that significantly affects quality of life. Despite therapeutic advances, challenges like treatment burden and limited care access persist.
Rodolfo Delfini Cançado, Paula de Melo Campos, Diego Kashiura, Felipe Thies, Erica Ferreira, Ana Beatriz Machado de Almeida, Lays Paulino Leonel, Lucas Vieira Cortez, Nina Melo, Fabio Fedozzi, Alessandro Bigoni   +10 more
doaj   +1 more source

Anemia and Patient‐Reported Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: A Real‐World Observational Study

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by complement‐mediated hemolysis, thrombosis, bone marrow failure, and anemia. Although current treatments improve outcomes, patients still experience hemolysis and could remain anemic with a negative impact on quality of life (QoL).
Esther Natalie Oliva, Antonio M Risitano, Eros Di Bona, Alessandro Maria Vannucchi, Ilaria Maria Dellfino, Antonio De Vivo, Valentina Giai, Rosario Notaro, Giuseppe Iannì, Eloise Beggiato, Simona Sica, Gaetano La Barba, Sneha Balakrishnan, Joanna Large, Tanuja Thavarajah, Simona Raso, Raffaele Fontana, Wilma Barcellini, Bruno Fattizzo, Roochi Trikha, Luana Marano, Jens Panse, Austin G Kulasekararaj   +22 more
wiley   +1 more source

Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm

, 2016
Yarden S Fraiman,1,2 Nathan Cuka,3 Denise Batista,3 Milena Vuica-Ross,3 Alison R Moliterno4 1Department of Pediatrics, Harvard Medical School, 2Department of Pediatrics, Boston University School of Medicine, Boston, MA, 3Department of Pathology ...
Cuka N, Batista D, Moliterno AR, Fraiman YS, Vuica-Ross M   +4 more
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Study of Anticoagulant, Procoagulant, and Fibrinolytic Pathways in Mexican Patients With Paroxysmal Nocturnal Hemoglobinuria

, 2023
In Mexico, the frequency of thromboembolic events associated to paroxysmal nocturnal hemoglobinuria is 3%; a clone size > 50% in granulocytes has been associated with a higher risk of thromboembolic events.
Scherling Ocampo, Aldo A., Vargas Ruíz, Angel G., López Karpovitch, Xavier   +2 more
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Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents

, 2008
Antonio M Risitano, Bruno RotoliHematology, Department of Biochemistry and Medical Biotechnologies, Federico II University of Naples, ItalyAbstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal non-malignant hematological disease characterized ...
RISITANO, ANTONIO MARIA, Bruno Rotoli, Antonio M Risitano, Rotoli B.   +3 more
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Mandibular osteomyelitis associated with paroxysmal nocturnal hemoglobinuria

, 2011
A case of osteomyelitis in a 71-year-old woman with paroxysmal nocturnal hemoglobinuria (PNH) is reported. Osteomyelitis of the jaw is a well known condition of the oral and maxillofacial region that may cause severe morbidity. It is well documented that
G. Warfvinge, Warfvinge, Gunnar, Carlson, Kristina,, Björnstad, L, Petersson, Arne, M. Kharazmi, Petersson, A, K. Carlson, Kharazmi, M, Petersson, Arne,, Kharazmi, Mohammad, Warfvinge, Gunnar,, Carlsson, Kristina, A. Petersson, Björnstad, Lillemor, L. Björnstad, Warfvinge, G   +16 more
core   +1 more source