Results 171 to 180 of about 47,778 (228)

Bioengineered exosome-mRNA hybrids: a breakthrough in targeted miRNA delivery for diabetic kidney fibrosis therapy. [PDF]

Front Bioeng Biotechnol
Ke J, Cao L, Zhang S, Xing J.
europepmc   +1 more source

Ингибиторы parp1: разработка противоопухолевых препаратов

Acta Naturae (русскоязычная версия), 2015
Одной из перспективных молекулярных мишеней для поиска противоопухолевых средств является поли(АDP-рибозо)полимераза 1 (PARP1), распространенный ядерный белок (1-2 млн молекул на клетку), выполняющий функцию «сенсора» разрывов ДНК. Экспрессия PARP1 повышена при меланомах, раке легкого, молочной железы и других опухолевых заболеваниях.
openaire   +1 more source

Interplay Between Poly(ADP-ribosyl)ation and Specific Inner Cellular Events That Suggest Combination Strategies for Overcoming PARP Inhibitor Resistance. [PDF]

Pharmaceutics
Xu L, Kong X, Zhang B, Ma H, Li X, Deng Y, Liu W, Ren W, Tang X, Zhang D.   +9 more
europepmc   +1 more source

Enhancing Veliparib PARP1 inhibitor stability against UVC degradation <i>via</i> DPPG liposome encapsulation. [PDF]

RSC Adv
Conceição CJF, Moe E, Ribeiro PA, Raposo M.   +3 more
europepmc   +1 more source

Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited. [PDF]

Mol Psychiatry
Cohen-Armon M, Segal M.
europepmc   +1 more source

Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer. [PDF]

Cancer Res
Herzog SK, Stevens JH, Gu G, Grimm SL, Cardoza K, Hawkins AGM, Lin H, Ramos D, Beyer AR, Edwards DG, Dustin D, Yang HJ, Liang N, Khan AF, Bawa-Khalfe T, McGrail DJ, Lin SY, Coarfa C, Fuqua SAW.   +18 more
europepmc   +1 more source

Design, synthesis and anti-breast cancer activity evaluation of 6,7-dihydro-5<i>H</i>-pyrrolo[3,4-<i>d</i>]pyrimidine-based PARP1/ATR dual inhibitors. [PDF]

J Enzyme Inhib Med Chem
He ML, Wang ZH, Yao X, Ye LL, Du BQ, Wang CC, Chen YH, Wang XX, Luo H, Gao Y, Ye XY.   +10 more
europepmc   +1 more source

PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation. [PDF]

Sci Adv
Zhu X, Huo Q, Jin L, Du J, Yu J, Wang H, Wu N, Li Y, Rui Y, Zhao C, Zhou J, Zhang Y, Li H, Lin J, Zheng C, Li W.   +15 more
europepmc   +1 more source

PJ34 Prevents Trauma-Induced Heterotopic Ossification without Adverse Bone Healing: An in vivo and in vitro Investigation. [PDF]

Drug Des Devel Ther
Zhang W, Hou J, Feng H, Zhu J, Liang Y, Mu W, Xu P, Qian Y, Jiang S.   +8 more
europepmc   +1 more source

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death [PDF]

, 2019
al., et, Ellenberger, Tom, Houl, Jerry H., Kim, In-Kwon, Stegeman, Roderick A.   +4 more
core   +1 more source