Results 181 to 190 of about 39,225 (199)
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Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader
Cell Death and DiseasePoly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells.
Li Chen +9 more
semanticscholar +1 more source
EZH2 directly methylates PARP1 and regulates its activity in cancer
Science AdvancesDNA repair dysregulation is a key driver of cancer development. Understanding the molecular mechanisms underlying DNA repair dysregulation in cancer cells is crucial for cancer development and therapies.
Qingshu Meng +22 more
semanticscholar +1 more source
The Discovery of a Potent PARP1 Inhibitor Senaparib
Molecular Cancer TherapeuticsAbstract PARP1 is a critical enzyme involved in DNA damage repair. It belongs to a superfamily of proteins and catalyzes poly(ADP-ribosyl)ation (PARylation). PARP1 inhibitors are effective to treat tumors that have homologous recombination deficiency such as those with BRCA1/2 mutations.
Sui X. Cai +5 more
openaire +2 more sources
MYC, PARP1, and Chemoresistance: BIN There, Done That?
Science Signaling, 2011Enhanced capacity for DNA repair may contribute to chemoresistance in cancers with dysregulated c-MYC.
openaire +2 more sources
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012
Qing-Wei HUO, Dong-Feng LI, Cheng LONG
openaire +1 more source
Qing-Wei HUO, Dong-Feng LI, Cheng LONG
openaire +1 more source
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer
Molecular Cell, 2021Johannes Rudolph +2 more
exaly
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
Nucleic Acids Research, 2020Brian J Lee +2 more
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