Results 171 to 180 of about 32,646 (215)

Tracking DNA damage localization and chromatin remodeling in live cells using time-resolved quantitative analysis of DNA counterstains. [PDF]

Cell Mol Life Sci
Paternò G, Longo E, Lanzanò L.
europepmc   +1 more source

CHD1L maintains genome integrity by facilitating okazaki fragment maturation. [PDF]

Nucleic Acids Res
Nie L, Fu J, Huang M, Zhang H, Ma T, Yang C, Li S, Wang C, Chen J.   +8 more
europepmc   +1 more source

Excessive poly(ADP)-ribosylation in the inflamed mucosa of pediatric celiac disease points to a novel inflammatory mechanism and therapeutic target. [PDF]

Mol Cell Pediatr
Haddadin TM, Masannat TM, Sheikh IA, Sun B, Kelley CP, Ghishan FK, Kiela PR.   +6 more
europepmc   +1 more source

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling. [PDF]

Nat Commun
Dauben H, Mihaljević M, Kolvenbach A, Palumbieri MD, Kapsali C, Huppertz I, Matić I.   +6 more
europepmc   +1 more source

Nucleotide excision repair and poly(ADP-ribose) polymerase 1 cooperate in HBV cccDNA synthesis: A potential viral therapeutic target. [PDF]

JHEP Rep
Hung HC, Tsai HW, Li YT, Liu WC, Cheng KH, Yen CJ, Lee YP, Fang YH, Chuang CH, Wu HL, Chang TT, Huang W.   +11 more
europepmc   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]

PeerJ
Fan J, Song Y.
europepmc   +1 more source

Recognition and confirmation of key genes associated with nicotinamide metabolism in acute myocardial infarction. [PDF]

Hereditas
Qu N, Bai F, Lan J.
europepmc   +1 more source

cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells. [PDF]

Front Oncol
Ouyang Y, Qin Y, Zhang Q, Zhu P, Zhu H.
europepmc   +1 more source

HPF1 regulates the formation of FUS-dependent compartments by PARP1 and PARP2 activation on damaged DNA. [PDF]

Nucleic Acids Res
Singatulina AS, Sukhanova MV, Hamon L, Kutuzov MM, Pastré D, Lavrik OI.   +5 more
europepmc   +1 more source

Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

Pharmacological Research, 2022
Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP represents a promising strategy for cancer therapy. To date, numerous small molecule PARP1 inhibitors have been identified, but many of them suffer from limited clinical efficacy ...
Xiaopeng Peng, Weijie Peng, Wanyi Pan
exaly   +3 more sources