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Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer. [PDF]

BMC Pharmacol Toxicol
Arora M, Yaseen YS, Mahmood AAR, Sangi SMA, Sangi SMA, Nagaraja S, Kurmi SPC, Thapa S.   +7 more
europepmc   +1 more source

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The complex universe of inactive PARP1

Trends in Genetics
Poly(ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family, which modifies targets through ADP-ribosylation and plays key roles in a variety of biological processes.
Doudou Huang, Z. Su, Yanxia Mei, Zhengping Shao   +3 more
exaly   +4 more sources

Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery

Molecular Cell, 2022
PARP1 rapidly detects DNA strand break damage and allosterically signals break detection to the PARP1 catalytic domain to activate poly(ADP-ribose) production from NAD+. PARP1 activation is characterized by dynamic changes in the structure of a regulatory helical domain (HD); yet, there are limited insights into the specific contributions that the HD ...
Dragomir B Krastev, Stephen J Pettitt, Christopher J Lord   +2 more
exaly   +3 more sources

Pleiotropic role of PARP1: an overview

3 Biotech, 2021
Poly (ADP-ribose) polymerase 1 (PARP1) protein is encoded by the PARP1 gene located on chromosome 1 (1q42.12) in human cells. It plays a crucial role in post-translational modification by adding poly (ADP-ribose) (PAR) groups to various proteins and PARP1 itself by utilizing nicotinamide adenine dinucleotide (NAD +) as a substrate.
Vikas Kumar, Anurag Kumar, Khursheed Ul Islam Mir, Vandana Yadav, Shyam Singh Chauhan   +4 more
openaire   +2 more sources

NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis.

Neuron, 2023
Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how it can be prevented.
Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, D. Chui, Y. E. Chen, Zheng Sun, Erdan Dong, Yongjun Wang, Lemin Zheng   +39 more
semanticscholar   +1 more source

PARP1: A Promising Target for the Development of PARP1-based Candidates for Anticancer Intervention

Current Medicinal Chemistry, 2016
Poly(ADP-ribose) polymerase 1 (PARP1) inhibition, increasing chemosensitization and conferring independent antiproliferation against defective homologous recombination cells, has provided a unique opportunity for anticancer therapeutic intervention.
Xiaolei, Zhu, Xiaodong, Ma, Yongzhou, Hu
openaire   +2 more sources

Sleep tight thanks to Parp1

Nature Reviews Molecular Cell Biology, 2021
DNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.
openaire   +2 more sources