Results 261 to 270 of about 55,025 (289)

PARP1 and CBP lose their footing in cancer

Nature Structural & Molecular Biology, 2014
The human histone macroH2A.1.1 recruits activated PARP1 enzyme to chromatin through its poly(ADP-ribose)-binding macrodomain. New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.
Gyula, Timinszky, Andreas G, Ladurner
openaire   +2 more sources

Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.

Toxicon
Bacterial lipopolysaccharide (LPS) exposure is a key inducer of intestinal inflammatory injury in weaned piglets, resulting in decreased growth performance of pigs and causing severe economic losses to the swine industry; however, the mechanism of ...
Qirong Lu, Nan Wang, Defeng Wen, Pu Guo, Yu Liu, S. Fu, Chun Ye, Zhongyuan Wu, Yinsheng Qiu   +8 more
semanticscholar   +1 more source

The NAD+/PARP1/SIRT1 Axis in Aging

Rejuvenation Research, 2017
NAD+ levels decline with age in diverse animals from Caenorhabditis elegans to mice. Raising NAD+ levels by dietary supplementation with NAD+ precursors, nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), improves mitochondrial function and muscle and neural and melanocyte stem ...
Andrew R, Mendelsohn, James W, Larrick
openaire   +2 more sources

The dynamics and Regulation of PARP1 and PARP2 in response to DNA damage and during replication

DNA Repair
DNA strand breaks activate Poly(ADP-ribose) polymerase (PARP) 1 and 2, which use NAD+ as the substrate to covalently conjugate ADP-ribose on themselves and other proteins (e.g., Histone) to promote chromatin relaxation and recruit additional DNA repair ...
Hanwen Zhang, S. Zha
semanticscholar   +1 more source

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions

Proceedings of the National Academy of Sciences of the United States of America
Significance The cytotoxicity of PARP inhibitors used in the clinic to treat tumors with deficiencies in homology-directed repair mainly relies on the trapping of inhibited PARP1 on DNA breaks.
Siham Zentout, Victor Imburchia, Catherine Chapuis, Lena Duma, Kira Schützenhofer, Evgeniia A. Prokhorova, I. Ahel, Rebecca Smith, Sébastien Huet   +8 more
semanticscholar   +1 more source

Olaparib, PARP1 inhibitor in ovarian cancer

Expert Opinion on Investigational Drugs, 2012
Ovarian cancer is the most important cause of gynecological cancer-related mortality. Conventional treatments for advanced or recurrent disease offer limited results in terms of long-term responses and survival. Researches have recently focused on target therapies, which represent a new, promising, therapeutic approach, able to maximizing tumor kill ...
MARCHETTI, CLAUDIA, IMPERIALE, LUDOVICA, GASPARRI, MARIALUISA, PALAIA, INNOCENZA, Sandro Pignata, BONI, Terenzio, BELLATI, FILIPPO, BENEDETTI PANICI, PIERLUIGI, P. B. Panici   +8 more
openaire   +3 more sources

Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer.

DNA Repair
The mechanisms by which poly(ADP-ribose) polymerase 1 (PARP1) inhibitors (PARPi)s inflict replication stress and/or DNA damage are potentially numerous. PARPi toxicity could derive from loss of its catalytic activity and/or its physical trapping of PARP1
Nathan MacGilvary, Sharon B. Cantor
semanticscholar   +1 more source

Novel PARP1 Inhibitors for Treating Cancer

ACS Medicinal Chemistry Letters, 2023
Provided herein are novel PARP1 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.
openaire   +3 more sources

Current Advances in PARP1‐Targeted Theranostics

Journal of Labelled Compounds and Radiopharmaceuticals
ABSTRACTPoly (ADP‐ribose) polymerase 1 (PARP1) plays critical roles in DNA repair, chromatin regulation, and cellular equilibrium, positioning it as a pivotal target for therapeutic interventions in cancer and central nervous system (CNS) disorders.
Jie Tong, Baosheng Chen, Tommaso Volpi, Yawen Li, Paul A. Ellison, Zhengxin Cai   +5 more
openaire   +2 more sources

Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader

Cell Death and Disease
Poly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells.
Li Chen, Yahui Zou, Renhong Sun, Mei Huang, Xiaotong Zhu, Xiaoming Tang, Xiaobao Yang, Dake Li, Gaofeng Fan, Yu Wang   +9 more
semanticscholar   +1 more source