Results 271 to 280 of about 55,025 (289)
Some of the next articles are maybe not open access.
The Discovery of a Potent PARP1 Inhibitor Senaparib
Molecular Cancer TherapeuticsAbstract PARP1 is a critical enzyme involved in DNA damage repair. It belongs to a superfamily of proteins and catalyzes poly(ADP-ribosyl)ation (PARylation). PARP1 inhibitors are effective to treat tumors that have homologous recombination deficiency such as those with BRCA1/2 mutations.
Sui X. Cai +5 more
openaire +2 more sources
MYC, PARP1, and Chemoresistance: BIN There, Done That?
Science Signaling, 2011Enhanced capacity for DNA repair may contribute to chemoresistance in cancers with dysregulated c-MYC.
openaire +2 more sources
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012
Qing-Wei HUO, Dong-Feng LI, Cheng LONG
openaire +1 more source
Qing-Wei HUO, Dong-Feng LI, Cheng LONG
openaire +1 more source
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer
Molecular Cell, 2021Johannes Rudolph +2 more
exaly
BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments
NatureSudipta Lahiri +6 more
semanticscholar +1 more source
A PARP1-TIMELESS alliance in cancer therapy
Molecular CellIn a recent paper in Nature, Petropoulos et al.1 report that PARP1 acts together with the replisome components TIMELESS and TIPIN to protect the genome from transcription-replication conflicts, which has important implications for the clinical use of PARP inhibitors.
openaire +2 more sources
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
Nucleic Acids Research, 2020Brian J Lee +2 more
exaly