Results 221 to 230 of about 103,862 (301)

PARP inhibitors restore NK cell function via secretory crosstalk with tumor cells in prostate cancer. [PDF]

J Clin Invest
Chao Z, Li L, Hao X, Peng H, Wang Y, Zhang C, Guo X, Liu P, Ma S, Zhang J, Qu G, Peng Y, Wei Z, Luo J, Liu B, Lan P, Wang Z.   +16 more
europepmc   +1 more source

A Design of Experiments‐Based Chiral HPLC Method for the Quantification of Talazoparib and Enantiomeric Purity Determination in Pharmaceutical Formulations

Chirality, Volume 38, Issue 4, April 2026.
A design of experiments–based chiral HPLC method was developed for the enantiomeric separation and quantification of talazoparib in pharmaceutical formulations. Efficient resolution of the enantiomers (RS > 7) was achieved within 12 min. The method was validated and successfully applied to tablet analysis, and its environmental sustainability was ...
Sakine Atila Karaca, Sona Aliyeva, Duygu Yeniceli   +2 more
wiley   +1 more source

The Landscape of PARP Inhibitors in Solid Cancers. [PDF]

Onco Targets Ther
Muzzana M, Broggini M, Damia G.
europepmc   +1 more source

Periodontitis and extracellular vesicles: Emerging roles in inflammation, tissue destruction and systemic crosstalk

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Extracellular vesicles released from periodontal tissues and pathogens mediate local inflammation and disseminate systemically via the circulation. By transporting regulatory microRNAs and inflammatory cytokines, these vesicles link periodontitis to systemic inflammatory conditions and represent emerging targets for minimally invasive diagnostics and ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

Emerging Therapeutic Synergies: Combining PD-1 Inhibitors With Poly-ADP-Ribose Polymerase (PARP) Inhibitors in the Treatment of Gynecologic Cancers. [PDF]

Cureus
Mohamed Azhar MS, Loh Z, Mutamba FT, Algahiny A, Yunusa NM, Paramasevon S, Almusarhed M.   +6 more
europepmc   +1 more source

Adequacy evaluation of 22‐gauge needle endoscopic ultrasound‐guided tissue acquisition samples and glass slides preparation for successful comprehensive genomic profiling testing: A single institute experience

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Objectives This study aimed to evaluate the successful sequencing rate of Foundation One CDx (F1CDx) using small tissue samples obtained with a 22‐gauge needle (22G) through endoscopic ultrasound‐guided fine needle acquisition (EUS‐TA) and to propose guidelines for tissue quantity evaluation criteria and proper slide preparation in clinical ...
Tami Nagatani, Yoji Wani, Masahiro Takatani, Soichiro Fushimi, Hirofumi Inoue, Shinichiro Hori, Kyohei Kai, Hideki Yamamoto, Tetsuya Okazaki, Maki Tanioka, Hiroyuki Okada, Akira Hirasawa   +11 more
wiley   +1 more source

Venous thromboembolic event risk with PARP inhibitors in solid tumors: a systematic review and meta-analysis. [PDF]

ESMO Open
Yazgan SC, Yekedüz E, Akkuş E, Sun M, Gillessen S, Fizazi K, McKay RR, Ay C, Castro E, Agarwal N, Choueiri TK, Ürün Y.   +11 more
europepmc   +1 more source

Patient and Public Involvement Reporting Consistency: Analysis of 24 Clinical Practice Guidelines From 4 Countries

Clinical and Public Health Guidelines, Volume 3, Issue 2, April 2026.
ABSTRACT Objective We compared the reporting of patient and public involvement (PPI) in the development of clinical practice guidelines (CPG) with the guidance regarding PPI in the auspicing organisation's guideline development manual. Methods We examined the PPI guidance provided by seven guideline auspicing organisations from four countries, that ...
Elizabeth Ann Bryant, Rae Thomas, Sharon Lea Sanders   +2 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer. [PDF]

Mol Oncol
Cunningham ML, Vasquez-Gonzalez J, Barnada SM, Tchotorlishvili S, Jones L, Maguire R, Lewis G, Rizwan K, Deng J, Koachar S, Patel D, Shankle H, Mulders T, Ajmal N, Solomides C, Alnemri ES, Alnemri TF, Shafi AA, Gomella LG, Kelly WK, McMahon SB, Schiewer MJ.   +21 more
europepmc   +1 more source

Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes.
Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Tainus Ali, Sajjad Karim, Loubna Siraj Mira, Fahd Al‐Abbasi, Murad Aljiffry, Mohammed Ghunaim, Abdulrahman Sibiany, Peter Natesan Pushparaj   +10 more
wiley   +1 more source