Results 231 to 240 of about 74,852 (258)

Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation

European Journal of Haematology, Volume 117, Issue 1, Page 132-143, July 2026.
ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Mamdouh Skafi, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Editorial: PARP inhibitors resistance: new insights in ovarian cancer therapy. [PDF]

Front Oncol
Fiste O, Liontos M, Labidi-Galy SI.
europepmc   +1 more source

PAK1 inhibition synergistically enhances the anti-tumor efficacy of PARP inhibitors in ovarian cancers. [PDF]

Genes Dis
Li C, Li X, Gao M, Deng M, Li YX, Lou Z.
europepmc   +1 more source

Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer. [PDF]

Cancer Sci
Tani M, Hatano K, Ishizuya Y, Oka T, Kanaki T, Inoguchi S, Yoshimura A, Horibe Y, Liu Y, Nesrine S, Okuda Y, Yamamoto A, Uemura T, Yamamichi G, Hayashi T, Yamamoto Y, Kato T, Kawashima A, Yamaguchi T, Obika S, Yusa K, Nonomura N, Nimura K.   +22 more
europepmc   +1 more source

Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging. [PDF]

EJNMMI Radiopharm Chem
Destro G, Rizzo R, Rua C, Azimi RR, Morbelli S.   +4 more
europepmc   +1 more source

Receipt of PARP Inhibitors in Patients With Metastatic Prostate Cancer Harboring BRCA1/2 Alterations.

JAMA Netw Open
Ostrowski M, Jo Y, Hage Chehade C, Ozay ZI, Gebrael G, Sayegh N, Lin E, Srivastava A, Gordhamer A, Ji R, Li H, Mathew Thomas V, Gupta S, Riaz IB, Maughan BL, Roy S, Agarwal N, Swami U.   +17 more
europepmc   +1 more source