Results 231 to 240 of about 104,861 (298)

PARP inhibitors restore NK cell function via secretory crosstalk with tumor cells in prostate cancer. [PDF]

J Clin Invest
Chao Z, Li L, Hao X, Peng H, Wang Y, Zhang C, Guo X, Liu P, Ma S, Zhang J, Qu G, Peng Y, Wei Z, Luo J, Liu B, Lan P, Wang Z.   +16 more
europepmc   +1 more source

DNA recognition, cleavage, and toxic metal ion interaction of an artificial zinc finger protein inside E. coli cells

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Zinc finger proteins are essential for the proper functioning of eukaryotic organisms, while their artificial variants can be used in cancer therapy or gene editing via their specific DNA recognition. Zn(II) binding is indispensable for the structural integrity of zinc fingers.
Bálint Hajdu, Annamária Tóth, Bettina Fazekas, Melinda Horvát, Kohsuke Kato, Atsushi Kawaguchi, Kyosuke Nagata, Attila Jancsó, Béla Gyurcsik   +8 more
wiley   +1 more source

Emerging Therapeutic Synergies: Combining PD-1 Inhibitors With Poly-ADP-Ribose Polymerase (PARP) Inhibitors in the Treatment of Gynecologic Cancers. [PDF]

Cureus
Mohamed Azhar MS, Loh Z, Mutamba FT, Algahiny A, Yunusa NM, Paramasevon S, Almusarhed M.   +6 more
europepmc   +1 more source

CEACAM6: A potential prognostic biomarker and therapeutic target in cholangiocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Jia‐Qi Guo, Shi‐Jia Dai, Yang Liu, Zhen‐Gang Yuan   +3 more
wiley   +1 more source

Socioeconomic and Demographic Factors in Genetic Testing Utilization Among Advanced Prostate Cancer Patients

The Prostate, Volume 86, Issue 8, Page 941-948, June 2026.
ABSTRACT Purpose Germline genetic testing in patients with advanced prostate cancer (PCa) is underutilized and hypothesized to be impacted by socioeconomic and demographic factors. This single institution, retrospective study assessed the association of income and social vulnerability with genetic referrals and testing.
Alexandra T. Skowron, Karen Childers, Courtney M. Rose, Kyle C. McElyea, Avery K. Supernois, Yousuf Hussain, Mohammed Baseer, Sunita Ghosh, Clara Hwang   +8 more
wiley   +1 more source

Venous thromboembolic event risk with PARP inhibitors in solid tumors: a systematic review and meta-analysis. [PDF]

ESMO Open
Yazgan SC, Yekedüz E, Akkuş E, Sun M, Gillessen S, Fizazi K, McKay RR, Ay C, Castro E, Agarwal N, Choueiri TK, Ürün Y.   +11 more
europepmc   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer. [PDF]

Mol Oncol
Cunningham ML, Vasquez-Gonzalez J, Barnada SM, Tchotorlishvili S, Jones L, Maguire R, Lewis G, Rizwan K, Deng J, Koachar S, Patel D, Shankle H, Mulders T, Ajmal N, Solomides C, Alnemri ES, Alnemri TF, Shafi AA, Gomella LG, Kelly WK, McMahon SB, Schiewer MJ.   +21 more
europepmc   +1 more source

Real‐world prevalence of PD‐L1 positivity in early‐stage/metastatic triple‐negative breast cancer: primary results and pathology insights from the global retrospective observational VANESSA study

Histopathology, Volume 88, Issue 7, Page 1373-1384, June 2026.
In the real‐world VANESSA study in triple‐negative breast cancer, PD‐L1‐positive prevalence was 38% in early‐stage and 20% in metastatic tumours, lower than in prospective trials. The lower prevalence in smaller versus larger tissue samples and by local versus central assessment underlines the importance of robust PD‐L1 testing to determine eligibility
Corrado D'Arrigo, Sitki Tuzlali, Romualdo Barroso‐Sousa, Nagi S El Saghir, Rebecca Dent, Nataša Medić‐Milijić, Gyungyub Gong, Shahin Sayed, Tu Thai Anh, Alisan Zirtiloglu, Götz Hartleben, Paula Toro, Iman Estaytieh, Enya Weber, Regula Deurloo, João Mouta, Lazar Popovic   +16 more
wiley   +1 more source