Results 51 to 60 of about 6,402,525 (303)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Combining school with part-time work: Empirical findings from Germany

open access: yesPapers, 2015
This article begins by outlining the current state of research into the issue of part-time work taken by secondary school students. The findings for Germany are based on a childhood and youth survey (AID:A).
Eric van Santen   +2 more
doaj   +1 more source

Part-Time Work and Industry Growth [PDF]

open access: yesFinance and Economics Discussion Series, 1998
The impression that employment in the U.S. has become more part-time intensive may be driven by a tendency for faster-growing industries to use more part-time work. I document this association over 1983-1993, and demonstrate that it is robust to alternative measures. Similar relationships are discernable in several countries.
openaire   +3 more sources

Q&A on working part-time in academia

open access: yesCommunications Chemistry, 2023
Dr Zoe Schnepp and Professor David Smith share their experiences of working part-time in academia, discussing some of the benefits and challenges, and offering advice to those who may be seeking to work part-time.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Part-Time Work and Work Hour Preferences. An International Comparison

open access: yesEuropean Sociological Review, 2013
The goal of this article is to explain cross-country differences in over- and under-employment. The focus is on the effects of the growth of part-time work. We argue and demonstrate that the spread and acceptance of part-time work results in a downward adaptation of descriptive norms regulating work hours.
Wielers, Rudolf   +2 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Aménagement des fins de carrière : entre reconfiguration des temps sociaux et transformations normatives

open access: yesSociologies, 2013
The aim of this paper is to understand the transformations of current temporalities through the end of career. We will show how the development of specific legal devices of reduction of working time in Belgium transforms the experiences of aging workers ...
Nathalie Burnay
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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