Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Part-time work in EU countries: labour market mobility, entry and exit [PDF]
This paper looks at the role of part-time work in labour mobility for 11 European countries. We find some evidence of part-time work being used as a stepping stone into full-time employment, but for a small proportion of individuals (less than 5%).
Buddelmeyer, Hielke +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The part-time pay penalty in a segmented labor market [PDF]
Part-time work has recently received renewed attention in Spain as its Prime Minister, José LuÃs RodrÃguez Zapatero, has offered to use part-time (PT) work as a measure to increase labor market flexibility in the midst of the current economic crisis ...
DANIEL FERNANDEZ
core +2 more sources
Seniorers mulighet for gradvis nedtrapping fra arbeidslivet
Søkelys på Arbeidslivet, 2018 Med IA-avtalen og pensjonsreformen har redusert arbeidstid blitt utropt til et universalmiddel, som ikke bare skal redusere sykefraværet, men også holde flere uføre og eldre i arbeid.
Tove Midtsundstad
doaj +1 more source
Trajectories of marginal part-time work and risk of depression. Does job or income insecurity mediate the relation? [PDF]
Scand J Work Environ Health, 2023 Nielsen HB +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Part-time work: the co-production of a contested employment model for women in Austria and internationally, 1950s to 1980s. [PDF]
J Contemp Cent East Eur, 2023 Helfert V.
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
WP 36 - Women's Preferences or Delineated Policies? The development or part-time work in the Netherlands, Germany and the United Kingdom [PDF]
Within sociological and economic analyses of working time, important questions remain regarding women’s ability to combine paid and domestic work. While there is a growing body of research in this area, our knowledge and understanding of the relationship
Mara Yerkes, Jelle Visser
core