Results 91 to 100 of about 205,233 (331)

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Novel 3D‐Printed Biophotonic Scaffold Displaying Luminescence under Near‐Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release

Advanced Healthcare Materials, EarlyView.
Despite significant efforts in developing novel biomaterials to regenerate tissue, only a few of them have successfully reached clinical use. It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial‐temporal manner, and trigger ...
Sonya Ghanavati, Ekin Opar, Virginia Alessandra Gobbo, Carlo Matera, Fabio Riefolo, Rossella Castagna, Julien Colombelli, Andrew Draganski, Joshua Baggott, Mika Lastusaari, Pau Gorostiza, Laeticia Petit, Jonathan Massera   +12 more
wiley   +1 more source

Dwell time of a Brownian interacting molecule in a cellular microdomain [PDF]

, 2006
The time spent by an interacting Brownian molecule inside a bounded microdomain has many applications in cellular biology, because the number of bounds is a quantitative signal, which can initiate a cascade of chemical reactions and thus has ...
Holcman, David, Taflia, Adi
core  

Serotonin system implication in L-DOPA-induced dyskinesia: from animal models to clinical investigations [PDF]

, 2014
In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA
CARTA, MANOLO, TRONCI, ELISABETTA
core   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression

Drug Design, Development and Therapy, 2016
Dawn Bruijnzeel, Rajiv Tandon Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA Abstract: Antipsychotic agents, utilized for the treatment of a range of psychiatric disorders, differ substantially in terms of ...
Bruijnzeel D, Tandon R
doaj  

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals [PDF]

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Ana M. Soto, Anette Møller, Anita Oles-Karasko, Anna-Maria Andersson, Bigsby RM, Birgitte Gissel, Bodil Korsgaard, Carlos Sonnenschein, Eva Bonefeld Jørgensen, Farzad Pakdel, Helle Raun Andersen, Henrik Leffers, Herman Autrup, Jesper Bo Nielsen, John McLachlan, John P. Sumpter, Klotz DM, Knud L. Pedersen, Korach KS, Kuiper GGJM, Levin W, Lisette B. Christiansen, Marianne Barfoed, Nicola A. Beresford, Nicolas Olea, Niels Erik Skakkebœk, Philippe Grandjean, Pilar Perez, Poul Bjerregaard, Remy Le Guevel, René Hummel, Soto AM, Soto AM, Steven F. Arnold, Susan M. Thorpe   +34 more
core   +2 more sources

Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs

Advanced Healthcare Materials, EarlyView.
Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller, Tamara Nink, Niklas Walter, Erick Angel Lopez Lopez, Hsin‐Fang Chang, Oskar Staufer   +5 more
wiley   +1 more source

Ractopamine HCl improved cardiac hypertrophy but not poor growth, metabolic inefficiency, or greater white blood cells associated with heat stress in concentrate-fed lambs [PDF]

, 2019
Heat stress decreases livestock performance and well-being (Hahn, 1999; Nienaber and Hahn, 2007), causes metabolic dysfunction that decreases growth efficiency (O’Brien et al., 2010), and alters cardiovascular function (Crandall et al., 2008). Each year,
Beede, Kristin A., Eggleston, Morgan L., Freeman, Micayla D., Petersen, Jessica L., Schmidt, Ty B., Swanson, Rebecca M., Yates, Dustin T.   +6 more
core   +1 more source

Is there a potential of misuse for Magnolia officinalis compounds/metabolites? [PDF]

, 2017
© 2017 John Wiley & Sons, Ltd.Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers ...
Alexeev, Böhmdorfer, Chiou, Coppola, Fattore, Fuchs, Fuchs, Garrison, Hattori, Kalman, Kao, Kotani, Kuribara, Lee, Lee, Lin, Liu, Mantani, Nakazawa, Oikawa, Papanti, Rempel, Schifano, Schifano, Schifano, Siemann, Sohn, Squires, Tsai, Tsai, Wang, Watanabe, Xu   +32 more
core   +3 more sources