Results 111 to 120 of about 205,233 (331)

Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients

Neuropsychiatric Disease and Treatment, 2018
Vanessa Torres-Llenza, Pooja Lakshmin, Daniel Z Lieberman Department of Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC, USA Abstract: The lack of long-term medication adherence is
Torres-Llenza V, Lakshmin P, Lieberman DZ   +2 more
doaj  

CXCL12 chemokine dimer signaling modulates acute myelogenous leukemia cell migration through altered receptor internalization

Scientific Reports
Acute myeloid leukemia (AML) is a malignancy of immature myeloid blast cells with stem-like and chemoresistant cells being retained in the bone marrow through CXCL12-CXCR4 signaling.
Donovan Drouillard, Michael Halyko, Elizabeth Cinquegrani, Maria Poimenidou, Miracle Emosivbe, Donna McAllister, Francis C. Peterson, Adriano Marchese, Michael B. Dwinell   +8 more
doaj   +1 more source

Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.

PLoS ONE, 2014
Partial agonists exhibit a submaximal capacity to enhance the coupling of one receptor to an intracellular binding partner. Although a multitude of studies have reported different ligand-specific conformations for a given receptor, little is known about ...
Ralf C Kling, Nuska Tschammer, Harald Lanig, Timothy Clark, Peter Gmeiner   +4 more
doaj   +1 more source

Dopamine Acts as a Partial Agonist for  2A Adrenoceptor in Melanin-Concentrating Hormone Neurons [PDF]

, 2011
Christian O. Alberto, Robert B. Trask, Michiru Hirasawa   +2 more
openalex   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic characteristics of aripiprazole

Psychiatry and Clinical Psychopharmacology, 2021
Efforts have continued to introduce new antipsychotics with different mechanisms of action following the clinical use of typical antipsychotics for the last fifty years. Among all atypical antipsychotics, aripiprazole has attracted attention since it is
Haldun Soygür
doaj  

Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations [PDF]

, 1977
Kinetic measurements are employed to reconstruct the steady-state activation of acetylcholine [Ach] receptor channels in electrophorus electroplaques. Neurally evoked postsynaptic currents (PSCs) decay exponentially; at 15°C the rate constant, α, equals ...
Lester, Henry A., Sheridan, Robert E.
core   +2 more sources

Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis

, 2022
Soyeon Shim, Maddeboina Krishnaiah, Madhusudana Reddy Sankham, Inha Kim, Yoseob Lee, Irin Shin, Areum Oh, Hwa Jeong Lee, Thi Ngoc Lan Vu, Jongmi Park, Sun Choi, Seojeong Park, Youngjoo Kwon, Sungsoon Fang, Dae‐Kee Kim   +14 more
openalex   +2 more sources

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

partial agonist

Citation: 'partial agonist' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.14174 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source