Results 111 to 120 of about 195,829 (332)
Advanced Science, EarlyView.Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui +19 more
wiley +1 more source
Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway [PDF]
, 2007 {gamma}-Aminobutyric acid type A (GABAA) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. Upon agonist binding, the receptor undergoes a structural transition from the closed to the open state, but the mechanism of gating ...
Dougherty, Dennis A. +2 more
core
Antagonists and partial agonists [PDF]
Nature, 1994 D. C. Parker, Philippa Marrack
openaire +2 more sources
Advanced Science, EarlyView.Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng +7 more
wiley +1 more source
Indian Journal of Psychological Medicine, 2013 Background: Depression is a neurological disorder characterized by sad mood, loss of pleasure, agitation and retardation. Though most relevant neuronal pathophysiology is characterized by decrease in monoamine namely; serotonin (5-HT), dopamine ...
Deepali Gupta +3 more
doaj +1 more source
Effect of xamoterol (ICI 118587), a new beta1 adrenoceptor partial agonist, on resting haemodynamic variables and exercise tolerance in patients with left ventricular dysfunction. [PDF]
, 1985 Adeniyi O. Molajo, Deborah H. Bennett
openalex +1 more source
Advanced Science, EarlyView.Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Zhaochen Guo +11 more
wiley +1 more source
RELATIVE POTENCY OF AGONIST AND PARTIAL AGONIST OPIOIDS
British Journal of Anaesthesia, 1985 M.D. Vickers, Michael Rosen
openaire +5 more sources
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension. [PDF]
JACC Basic Transl Sci, 2023 Valentine MS +16 more
europepmc +1 more source
Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations [PDF]
, 1977 Kinetic measurements are employed to reconstruct the steady-state activation of acetylcholine [Ach] receptor channels in electrophorus electroplaques. Neurally evoked postsynaptic currents (PSCs) decay exponentially; at 15°C the rate constant, α, equals ...
Lester, Henry A., Sheridan, Robert E.
core +2 more sources