Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
Advanced Science, EarlyView.TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang +9 more
wiley +1 more source
Varenicline: A new pharmacotherapy for smoking cessation in primary care practice
South African Family Practice, 2011 Background: Cigarette smoking causes significant morbidity and mortality and is a major public health concern worldwide. Primary care doctors are in a unique position that enables them to promote smoking cessation, as smokers are more aware of their ...
N. Robson
doaj +1 more source
Evaluation of the Sedative Properties of PK 8165 (Pipequaline). a Benzodiazepine Partial Agonist, in Normal Subjects [PDF]
, 1986 R. von Frenckell +2 more
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Ractopamine HCl improved cardiac hypertrophy but not poor growth, metabolic inefficiency, or greater white blood cells associated with heat stress in concentrate-fed lambs [PDF]
, 2019 Heat stress decreases livestock performance and well-being (Hahn, 1999; Nienaber and Hahn, 2007), causes metabolic dysfunction that decreases growth efficiency (O’Brien et al., 2010), and alters cardiovascular function (Crandall et al., 2008). Each year,
Beede, Kristin A. +6 more
core +1 more source
Enhanced Media Optimize Bovine Myogenesis in 2D and 3D Models for Cultivated Meat Applications
Advanced Science, EarlyView.This study uses multiomics approaches to characterize bovine myogenesis in vitro, identifying media components that enhance myogenic progenitor cell differentiation in 2D and 3D models. Notably, the enhanced conditions promoted formation of unique cell populations and contractile muscle cells expressing mature myogenic markers.
Christine L. Trautmann +4 more
wiley +1 more source
Comment on: Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys. [PDF]
Neuropsychopharmacology, 2023 Chong S, Comer SD.
europepmc +1 more source
Long‐term efficacy of xamoterol (a beta 1‐adrenoceptor partial agonist) in patients with mild to moderate heart failure. [PDF]
, 1989 EV Sorensen +3 more
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Advanced Science, EarlyView.This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo +10 more
wiley +1 more source
iScienceSummary: The dopamine D1 receptor (D1R) couples to Gαs and Gαolf and is crucial in regulating neurological and neuropsychiatric functions. In the brain, Gαolf is predominantly found in the striatum whereas Gαs is expressed elsewhere.
Anh Minh Nguyen +5 more
doaj +1 more source
Dwell time of a Brownian interacting molecule in a cellular microdomain [PDF]
, 2006 The time spent by an interacting Brownian molecule inside a bounded microdomain has many applications in cellular biology, because the number of bounds is a quantitative signal, which can initiate a cascade of chemical reactions and thus has ...
Holcman, David, Taflia, Adi
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