Results 141 to 150 of about 205,233 (331)

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans. [PDF]

Molecules, 2023
Lutz JA, Sulima A, Gutman ES, Bow EW, Luo D, Kaska S, Prisinzano TE, Paronis CA, Bergman J, Imler GH, Kerr AT, Jacobson AE, Rice KC.   +12 more
europepmc   +1 more source

Inertial Load Compensation by a Model Spinal Circuit During Single Joint Movement [PDF]

, 1995
Office of Naval Research (N00014-92-J-1309); CONACYT (Mexico ...
Bullock, Daniel, Contreas-Vidal, Jose Luis, Grossberg, Stephen   +2 more
core   +1 more source

386. Magic Factor-1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis [PDF]

, 2009
Marco Cassano, Stefano Biressi, Amanda Finan, Laura Benedetti, Claudia Omes, Renata Boratto, Frank Martin, Marcello Allegretti, Vania Broccoli, Gabriella De Angelis, Paolo Comoglio, Cristina Basilico, Yvan Torrente, Paolo Michieli, Giulio Cossu, Maurilio Sampaolesi, L Trusolino, P Comoglio, L Tamagnone, P Comoglio, R Zarnegar, G Michalopoulos, J Rubin, D Bottaro, S Aaronson, C Birchmeier, W Birchmeier, E Gherardi, Vande Woude, G, A Woolf, M Kolatsi-Joannou, P Hardman, E Andermarcher, C Moorby, H Takayama, La Rochelle, W Anver, M Bockman, D Merlino, G, E Andermarcher, M Surani, E Gherardi, F Maina, M Hilton, C Ponzetto, A Davies, R Klein, L Kos, A Aronzon, H Takayama, F Maina, C Ponzetto, C Schmidt, F Bladt, S Goedecke, V Brinkmann, W Zschiesche, Y Uehara, O Minowa, C Mori, K Shiota, J Kuno, F Bladt, D Riethmacher, S Isenmann, A Aguzzi, C Birchmeier, F Maina, F Casagranda, E Audero, A Simeone, P Comoglio, S Sheehan, R Tatsumi, C Temm-Grove, R Allen, K Miller, D Thaloor, S Matteson, G Pavlath, R Tatsumi, J Anderson, C Nevoret, O Halevy, R Allen, S Anastasi, S Giordano, O Sthandier, G Gambarotta, R Maione, R Gal-Levi, Y Leshem, S Aoki, T Nakamura, O Halevy, Y Leshem, D Spicer, R Gal-Levi   +99 more
openalex   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance

Neuropsychiatric Disease and Treatment, 2008
Angela F Caveney1, Bruno Giordani1, George M Haig21Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA; 2Neurosciences Development, Abbott Laboratories, Abbott Park, IL, USAAbstract: Pagoclone is a novel cyclopyrrolone that acts as a ...
Angela F Caveney, Bruno Giordani, George M Haig   +2 more
doaj  

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Effects of selective dopamine D3 receptor partial agonist/antagonists on oxycodone self-administration and antinociception in monkeys. [PDF]

Neuropsychopharmacology, 2023
Woodlief K, Allen MI, Cornelissen JC, Banks ML, Newman AH, Newman AH, Nader MA.   +6 more
europepmc   +1 more source

Impulse Control Disorders by Dopamine Partial Agonists: A Pharmacovigilance-Pharmacodynamic Assessment Through the FDA Adverse Event Reporting System [PDF]

, 2022
Michele Fusaroli, Emanuel Raschi, Valentina Giunchi, Marco Menchetti, Roberto Rimondini, Fabrizio De Ponti, Elisabetta Poluzzi   +6 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Case report: Open bite as an extrapyramidal side effect with aripiprazole, a dopamine partial agonist. [PDF]

Front Psychiatry, 2022
Sumi S, Nagamine T, Sumi K, Aijima R, Oka K, Toyofuku A.   +5 more
europepmc   +1 more source