Results 161 to 170 of about 205,233 (331)

PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats. [PDF]

Neuropharmacology, 2022
Cippitelli A, Martinez M, Zribi G, Cami-Kobeci G, Husbands SM, Toll L.   +5 more
europepmc   +1 more source

Discovery of a novel class of PPARδ partial agonists

, 2008
Barry G. Shearer, Hari S. Patel, Andrew N. Billin, James M. Way, Deborah A. Winegar, Millard H. Lambert, Robert X. Xu, Lisa M. Leesnitzer, Raymond V. Merrihew, Stéphane Huet, Timothy M. Willson   +10 more
openalex   +1 more source

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Advanced Science, EarlyView.
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M. Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S. L. Parker, Yingying Guo, Dongming Zhou   +12 more
wiley   +1 more source

The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice. [PDF]

Psychopharmacology (Berl), 2021
Wu R, Liu J, Seaman R, Johnson B, Zhang Y, Li JX, Li JX.   +6 more
europepmc   +1 more source

The Beta-Arrestin-Biased Dopamine D2 Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation [PDF]

, 2018
Richard Ågren, Peter Århem, Johanna Nilsson, Kristoffer Sahlholm   +3 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

RELATIVE POTENCY OF AGONIST AND PARTIAL AGONIST OPIOIDS

British Journal of Anaesthesia, 1985
M.D. VICKERS, M. ROSEN
openaire   +3 more sources

The Effects of a Novel Non-catechol Dopamine Partial Agonist on Working Memory in the Aged Rhesus Monkey. [PDF]

Front Aging Neurosci, 2021
Moore TL, Young DA, Killiany RJ, Fonseca KR, Volfson D, Gray DL, Balice-Gordon R, Kozak R.   +7 more
europepmc   +1 more source

A Difference in Receptor Mechanisms for Muscarinic Full and Partial Agonists.

, 1991
Issei Takayanagi, Mariko Harada, Katsuo Koike   +2 more
openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source