Results 171 to 180 of about 205,233 (331)

nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity. [PDF]

Bioorg Med Chem Lett, 2022
Dekarske MM, Felix LO, Ortiz CM, Csatary EE, Mylonakis E, Wuest WM.   +5 more
europepmc   +1 more source

Antagonists and partial agonists [PDF]

Nature, 1994
P. M., D. C. P.
openaire   +1 more source

Study on the anxiolytic activity of Y-23684, a benzodiazepine receptor (BZR) partial agonist, in various rodent models of anxiety: A systematic comparison with other BZR ligands.

, 1994
Hiroshi Yasumatsu, Tunko Yamamoto, Shuzo Takehara, Takemi Fukuda   +3 more
openalex   +1 more source

F15063, a compound with D₂/D₃antagonist, 5‐HT_1Aagonist and D₄partial agonist properties: (II) Activity in models of positive symptoms of schizophrenia [PDF]

, 2007
Ronan Depoortère, Laurent Bardin, Agnès L. Auclair, Mark S. Kleven, E. Prinssen, Françis C. Colpaert, Bernard Vacher, Adrian Newman‐Tancredi   +7 more
openalex   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness. [PDF]

Nature, 2021
Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ.   +22 more
europepmc   +1 more source

Pharmacodynamic Characterization of ZP120 (Ac-RYYRWKKKKKKK-NH2), a Novel, Functionally Selective Nociceptin/Orphanin FQ Peptide Receptor Partial Agonist with Sodium-Potassium-Sparing Aquaretic Activity

, 2005
Daniel R. Kapusta, Christian Thorkildsen, Velga A. Kenigs, Eddi Meier, Mette M. Vinge, Charlotte F. Quist, Jørgen S. Petersen   +6 more
openalex   +1 more source

Adenosine 5’-O-(2-Thiodiphosphate) (ADP-β-S) Is A Partial Agonist At The ADP Receptor Of Human Platelets [PDF]

, 1981
Noel J. Cusack, S.M.O. Hourani
openalex   +1 more source

A1 Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic? [PDF]

, 2020
Fabrizio Vincenzi, Silvia Pasquini, Enrica Battistello, Stefania Merighi, Stefania Gessi, Pier Andrea Borea, Katia Varani   +6 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source