Results 181 to 190 of about 195,829 (332)

The Effect of the Partial Beta-1-Adrenoceptor Agonist Xamoterol on Hemodynamics and Myocardial Energetics in Patients with Idiopathic Dilated Cardiomyopathy

, 1991
Ludwig Thierfelder, Christian Holubarsch, Gerd Hasenfuß, Hans Wolfgang Hei, Hanjörg Just   +4 more
openalex   +1 more source

Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors [PDF]

, 1997
Jonathan S. Marchant, Young‐Tae Chang, Sung-Kee Chung, Robin F. Irvine, Colin W. Taylor   +4 more
openalex   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

Human perceptual learning is delayed by the N-methyl-D-aspartate receptor partial agonist D-cycloserine. [PDF]

J Psychopharmacol, 2021
Dempsey-Jones H, Steudte-Schmiedgen S, Browning M, Makin TR, Woud ML, Harmer CJ, Margraf J, Reinecke A.   +7 more
europepmc   +1 more source

The D136A mutation of the V₂vasopressin receptor induces a constitutive activity which permits discrimination between antagonists with partial agonist and inverse agonist activities [PDF]

, 1998
Denis Morin, Nathalie de la Cotte, Marie‐Noëlle Balestre, Bernard Mouillac, Maurice Manning, Christophe Breton, Claude Barberis   +6 more
openalex   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

A Difference in Receptor Mechanisms for Muscarinic Full and Partial Agonists.

, 1991
Issei Takayanagi, Mariko Harada, Katsuo Koike   +2 more
openalex   +1 more source

Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists [PDF]

, 1995
Mary H. Richards, Paul L. M. van Giersbergen   +1 more
openalex   +1 more source

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source

Use of microdoses for induction of buprenorphine treatment with overlapping full opioid agonist use: the “Bernese method”

Substance Abuse and Rehabilitation, 2016
Robert Hämmig,1 Antje Kemter,2 Johannes Strasser,2 Ulrich von Bardeleben,1 Barbara Gugger,1 Marc Walter,2 Kenneth M Dürsteler,2 Marc Vogel2 1Division of Addiction, University Psychiatric Services Bern, Bern, Switzerland; 2Division of Substance ...
Hämmig R, Kemter A, Strasser J, von Bardeleben U, Gugger B, Walter M, Dürsteler KM, Vogel M   +7 more
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