Results 201 to 210 of about 195,829 (332)

A highly D₃R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D₃R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder. [PDF]

Neuropsychopharmacology, 2022
Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH.   +16 more
europepmc   +1 more source

Stereoselectivity in beta-adrenoceptor of beta-adrenergic partial agonists, befunolol and carteolol! isolated rabbit ciliary body and guinea-pig taenia caecum.

, 1991
Hisashi Hagiwara, Katsuo Koike, Issei Takayanagi   +2 more
openalex   +1 more source

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Different conformational responses of the β₂-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline. [PDF]

Natl Sci Rev, 2021
Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C.   +11 more
europepmc   +1 more source

Anxioselective abecarnil acting as a selective partial agonist at central benzodiazepine BZ1 receptors

, 1992
Masaki Ozawa, Yukie Nakada, Keiko Sugimachi, Mayumi Tsuzaki, Tetsuo Akai, Motonori Yamaguchi   +5 more
openalex   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models. [PDF]

Nat Commun
Robert J, Feuillolay M, de Temple-Llavero M, Akossi RF, Mhanna V, Cheraï M, Fourcade G, Charlotte F, Tchitchek N, Mi T, Youngblood B, Vazquez T, Rosenzwajg M, Klatzmann D.   +13 more
europepmc   +1 more source

Time course for blood pressure lowering of beta-blockers with partial agonist activity. [PDF]

Cochrane Database Syst Rev, 2020
Zhang XY, Soufi S, Dormuth C, Musini VM.
europepmc   +1 more source

First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M₁ -receptor partial agonist for the treatment of dementias. [PDF]

Br J Clin Pharmacol, 2021
Bakker C, Tasker T, Liptrot J, Hart EP, Klaassen ES, Prins S, van der Doef TF, Brown GA, Brown A, Congreve M, Weir M, Marshall FH, Cross DM, Groeneveld GJ, Nathan PJ.   +14 more
europepmc   +1 more source

Study on the anxiolytic activity of Y-23684, a benzodiazepine receptor (BZR) partial agonist, in various rodent models of anxiety: A systematic comparison with other BZR ligands.

, 1994
Hiroshi Yasumatsu, Tunko Yamamoto, Shuzo Takehara, Takemi Fukuda   +3 more
openalex   +1 more source