Results 211 to 220 of about 195,829 (332)

New Antiprogestins with Partial Agonist Activity: Potential Selective Progesterone Receptor Modulators (SPRMs) and Probes for Receptor- and Coregulator-Induced Changes in Progesterone Receptor Induction Properties [PDF]

, 2001
Georgia Giannoukos, Daniele Szapary, Catharine L. Smith, James E. W. Meeker, S. Stoney Simons   +4 more
openalex   +2 more sources

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, EarlyView.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis. [PDF]

Front Chem
Wang Z, Shui K, Zhang Z, Chen Y, Yang N, Ji S, Shen P, Tian Q.   +7 more
europepmc   +1 more source

Partial to complete antagonism by putative antagonists at the wild‐type α_2C‐adrenoceptor based on kinetic analyses of agonist : antagonist interactions [PDF]

, 2000
Petrus J. Pauwels, Françis C. Colpaert
openalex   +1 more source

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

Ligand and Residue Free Energy Perturbations Solve the Dual Binding Mode Proposal for an A_2BAR Partial Agonist. [PDF]

J Phys Chem B
Tandarić T, Gutiérrez-de-Terán H.
europepmc   +1 more source

Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations. [PDF]

Comput Struct Biotechnol J, 2021
An X, Bai Q, Bing Z, Liu H, Yao X.
europepmc   +1 more source

Comparison of novel cannabinoid partial agonists and SR141716A in the guinea‐pig small intestine [PDF]

, 2000
Angela A. Coutts, Nicola Brewster, Tracey Ingram, Raj K. Razdan, Roger G. Pertwee   +4 more
openalex   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

Anti-Inflammatory and Antinociceptive Properties of the Quercetin-3-Oleate AV2, a Novel FFAR1 Partial Agonist. [PDF]

Int J Mol Sci
Pessina F, Casini I, Gamberucci A, Carullo G, Signorini C, Brizzi A, Aiello F, Aloisi AM, Pieretti S.   +8 more
europepmc   +1 more source