Results 221 to 230 of about 195,829 (332)

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

Effect of chronic delivery of the NOP/MOR partial agonist AT-201 and NOP antagonist J-113397 on heroin relapse in a rat model of opioid maintenance. [PDF]

Psychopharmacology (Berl)
Bossert JM, Caldwell KE, Korah H, Batista A, Bonbrest H, Fredriksson I, Jackson SN, Sulima A, Rice KC, Zaveri NT, Shaham Y.   +10 more
europepmc   +1 more source

Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel. [PDF]

J Physiol, 2020
Long W, Fatehi M, Soni S, Panigrahi R, Philippaert K, Yu Y, Kelly R, Boonen B, Barr A, Golec D, Campbell SA, Ondrusova K, Hubert M, Baldwin T, Lemieux MJ, Light PE.   +15 more
europepmc   +1 more source

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.

, 1996
Joaquı́n Madrenas, R H Schwartz, Ronald N. Germain   +2 more
openalex   +1 more source

Pharmacological Characterisation of the Enantiomers of BM‐5, a Muscarinic Partial Agonist with Opposed Enantioselectivity between Affinity and Efficacy* [PDF]

, 2000
Staffan Sundquist, Ali‐Reza Modiri, Björn M. Nilsson, Uli Hacksell, Per‐Göran Gillberg, Lisbeth Nilvebrant   +5 more
openalex   +1 more source

T cell receptor antagonists and partial agonists

Immunity, 1995
Stephen C. Jameson, Michael J. Bevan
openaire   +3 more sources

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Advanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan, Qingyi Dai, Jianhan Ren, Lijian Jin, Weiping Wang, Zhou Ye, James Kit Hon Tsoi, Yifan Lin   +7 more
wiley   +1 more source

Vilazodone, a Novel SSRI Antidepressant with 5-HT1A Partial Agonist Properties: Diminished Potentiation of Chronic Oral Methylphenidate-Induced Dynorphin Expression in the Striatum in Adolescent Male Rats. [PDF]

Mol Neurobiol
Hrabak M, Ahmed R, Soriano MG, Powell A, Thanos PK, Steiner H.   +5 more
europepmc   +1 more source

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science, EarlyView.
This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
wiley   +1 more source

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia. [PDF]

J Clin Invest
Whiteside GT, Kyle DJ, Kapil RP, Cipriano A, He E, Zhou M, Shet MS, Hummel M, Knappenberger T, Fukumura K, Matsuo Y, Uehira M, Hiroyama S, Takai N, Willsie SK, Harris SC.   +15 more
europepmc   +1 more source