Results 231 to 240 of about 195,829 (332)

Constitutive Androstane Receptor in Macrophages Regulates Toll‐Like Receptor 4‐Mediated Innate Immune Responses Against Endotoxemic Liver Injury

Advanced Science, EarlyView.
The present study uncovers a novel role of constitutive androstane receptor (CAR) in inflammation‐mediated damage. CAR activation in macrophages inhibits proinflammatory macrophages by interacting with Tlr4, which protects against endotoxemic liver injury.
Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang   +12 more
wiley   +1 more source

15-Keto-PGE₂ acts as a biased/partial agonist to terminate PGE₂-evoked signaling. [PDF]

J Biol Chem, 2020
Endo S, Suganami A, Fukushima K, Senoo K, Araki Y, Regan JW, Mashimo M, Tamura Y, Fujino H.   +8 more
europepmc   +1 more source

Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells [PDF]

, 2001
Christina Trollmo, A. Meyer, Allen C. Steere, David A. Hafler, Brigitte T. Huber   +4 more
openalex   +1 more source

Patients‐Derived Organoids Sequencing‐based FOXP4 Facilitates Radioresistance by Transcriptionally Modifying GPX4 to Regulate ferroptosis in Colorectal Cancer

Advanced Science, EarlyView.
FOXP4 regulates GPX4 transcription to suppress ferroptosis. In CRC patients, initial biopsies established PDO cultures alongside concurrent chemoradiotherapy. Post‐treatment MRI with mrTRG scoring stratified radioresistant/sensitive cohorts. Parallelly, 8Gy‐irradiated PDOs underwent viability‐based stratification.
Qianping Chen, Yuzhao Jin, Luyu Liao, Rong Shen, Xingnan Ge, Qingyu Jiang, Ying Huang, Quanquan Sun, Dong Liu, Luying Liu, Tongxin Liu, Qinghui Dai, Xiyuan Tang, Zhe Han, Xin Gao, Xinhua Lin, Wei Mao, Ji Zhu   +17 more
wiley   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Effects of GABA_A receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions [PDF]

, 2001
Suzanne L. Hansen, Bjarke Ebert, Bjarne Fjalland, Uffe Kristiansen   +3 more
openalex   +1 more source

Directed Self‐Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity

Advanced Science, EarlyView.
Magnetically guided bioceramic nanoparticles (“CalBots”) achieve deep dentinal tubule occlusion via directed self‐assembly under externally applied magnetic field. Various visualization techniques and a novel mouse behavioral assay indicate that CalBot‐induced plugs may reduce dentinal sensitivity, offering a promising strategy for future dentin ...
Shanmukh Peddi, Prajwal Hegde, Prannay Reddy, Anaxee Barman, Arnab Barik, Debayan Dasgupta, Ambarish Ghosh   +6 more
wiley   +1 more source

A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model. [PDF]

Alzheimers Dement
Latif-Hernandez A, Yang T, Butler RR, Losada PM, Minhas PS, White H, Tran KC, Liu H, Simmons DA, Langness V, Andreasson KI, Wyss-Coray T, Longo FM.   +12 more
europepmc   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [¹⁸F]DOPA PET in Naïve and Cocaine-Treated Mice. [PDF]

Mol Imaging
Bonsall DR, Kokkinou M, Halff EF, Rutigliano G, Tang SP, Veronese M, Irvine EE, Withers DJ, Wells LA, Natesan S, Gerlach I, Holiga Š, Hoener MC, Howes OD.   +13 more
europepmc   +1 more source