Results 291 to 300 of about 195,829 (332)

A Novel Flexible Approach for Evaluating Fixed Ratio Mixtures of Full and Partial Agonists

, 2004
Chris Gennings
openalex   +1 more source

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

The Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

Variation in parrot jaw musculature

The Anatomical Record, EarlyView.
Interspecific morphological differences in some superficial jaw muscles of parrots. Abstract Psittaciformes, the order encompassing parrots and their relatives, are highly diverse and generally known for having a strong beaks used for multiple behaviors. The muscles related to the masticatory apparatus should reflect this functional complexity; however,
Ana Carolina L. Faillace, Arin Berger, Marcelo Ismar S. Santana, Adam Hartstone‐Rose   +3 more
wiley   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, EarlyView.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing [PDF]

, 2019
Huettner, James E, Wilding, Timothy J
core   +1 more source

Gout and NLRP3 Inflammasome Biology

Arthritis &Rheumatology, EarlyView.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Monocyte‐derived macrophages‐synovial fibroblasts crosstalk unravels oncostatin signaling network as a driver of synovitis in osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Associations of specific pesticides and incident rheumatoid arthritis among female spouses in the Agricultural Health Study

Arthritis &Rheumatology, Accepted Article.
Objectives Growing evidence suggests farming and agricultural pesticide use may be associated with rheumatoid arthritis (RA), but few studies have examined specific pesticides and RA among farm women, who may personally use pesticides or be indirectly exposed.
Christine G. Parks, Darya Leyzarovich, Ghassan B. Hamra, Karen H. Costenbader, Dazhe Chen, Jonathan N. Hofmann, Laura E. Beane Freeman, Dale P. Sandler   +7 more
wiley   +1 more source

Narrative inquiry for beginners: A practical guide for health professions education researchers

Anatomical Sciences Education, EarlyView.
Abstract Narrative inquiry (NI) is a rich methodological approach centered around the analysis of stories. While NI has great value within health professions education research, it may be overwhelming for novice researchers (or those new to NI) to employ in practice.
Shemona Y. Rozario, Michelle D. Lazarus, Mahbub Sarkar, Melanie K. Farlie   +3 more
wiley   +1 more source

Is the Association Between Emotion Recognition and Social Functioning Mediated by Cognitive Empathy and Emotional Language? An Examination of School‐Aged Autistic Children

Autism Research, EarlyView.
ABSTRACT Children with autism spectrum disorder (ASD) face substantial challenges in understanding emotions, including difficulty in recognizing emotions through nonverbal cues, interpreting others' affective and mental states, and developing emotional vocabulary. Research suggests that the association between emotion recognition and social functioning
Ifat Bar, Sigal Eden, Ofer Golan
wiley   +1 more source