Results 321 to 330 of about 195,829 (332)
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Partial dopamine agonists in the treatment of psychosis
Journal of Neural Transmission, 2002The discovery and characterization of dopamine in the mammalian brain earned Dr. Arvid Carlsson the Nobel Prize in 2000. Along with his many insights about dopamine pharmacology, came his proposal of the existence and critical role of dopamine autoreceptors in the overall regulation of dopamine-mediated neurotransmission.
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Serotonergic agonists behave as partial agonists at the dopamine D2 receptor
NeuroReport, 1999RAT dopamine D2short receptors expressed in CHO cells were characterized by activation of [35S]GTPgammaS binding. There were no significant differences between the maximal effects seen in activation of [35S]GTPgammaS binding caused by dopaminergic agonists, but the effects of 5-HT, 8OH-DPAT and 5-methoxytryptamine amounted to 47 +/- 7%, 43 +/- 5% and ...
Sergi Ferré +4 more
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Pharmacotherapy for tobacco cessation: Nicotine agonists, antagonists, and partial agonists
Current Oncology Reports, 2007Nicotine replacement therapies (NRT) were the main pharmacologic option for treatment of nicotine dependence until the early 1990s, when controlled clinical trials confirmed the efficacy of bupropion, the first treatment not based on nicotine. Varenicline, a partial agonist at nicotine receptors, gained US regulatory approval in 2006 for smoking ...
Maher Karam-Hage, Paul M. Cinciripini
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ChemInform Abstract: Mixed Opioidic Agonists/Antagonists and Partial Agonists
ChemInform, 2002AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thomas Christoph, Helmut Buschmann
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Partial agonists for adenosine receptors
1996Publisher Summary This chapter discusses the partial agonists for adenosine receptors. Adenosine is generally considered as a “local hormone” with profound physiological activity. It is thought to mediate a large variety of effects, as diverse as vasodilation in the cardiovascular system, inhibition of lipolysis in fat cells, and depression of ...
J. K. Von Frijtag Drabbe Künzel +4 more
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Journal of Cardiovascular Pharmacology, 1983
The effect of bioactive agents in many, if not most, cases should be considered as the result of an interaction among molecules of the active agent, the drug, and particular molecular sites of action, receptors (sometimes enzymes), in the biological object. In those cases in which a drug-receptor interaction is involved, two essential parameters should
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The effect of bioactive agents in many, if not most, cases should be considered as the result of an interaction among molecules of the active agent, the drug, and particular molecular sites of action, receptors (sometimes enzymes), in the biological object. In those cases in which a drug-receptor interaction is involved, two essential parameters should
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Buprenorphine: The Opioid that Cried 'Partial Agonist'
Journal of Opioid ManagementBackground: Although buprenorphine use has increased dramatically over the past decade, its unique pharmacologic and pharmacokinetic profile often leads to misconceptions about its overall utility and has created a drastic underrepresentation in patients with chronic non-cancer pain.
Jeffrey J, Bettinger, Jacqueline, Cleary
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Partial Agonists in the Central Nervous System [PDF]
Nature, 1963 Glenda M. Laycock, A. Shulman
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Partial agonists and antagonists for substance P
European Journal of Pharmacology, 1983Jacques Mizrahi +4 more
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