Results 51 to 60 of about 195,829 (332)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders. [PDF]

PLoS ONE, 2017
The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated with Alzheimer's disease (AD).
Bitna Yi, Alam Jahangir, Andrew K Evans, Denise Briggs, Kristine Ravina, Jacqueline Ernest, Amir B Farimani, Wenchao Sun, Jayakumar Rajadas, Michael Green, Evan N Feinberg, Vijay S Pande, Mehrdad Shamloo   +12 more
doaj   +1 more source

Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling [PDF]

, 2007
G protein–coupled receptors (GPCRs) exist in multiple dynamic states (e.g., ligand-bound, inactive, G protein–coupled) that influence G protein activation and ultimately response generation. In quantitative models of GPCR signaling that incorporate these
Kinzer-Ursem, Tamara L., Linderman, Jennifer J.   +1 more
core   +3 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Aripiprazole-induced hyperprolactinemia in a young female with delusional disorder

Indian Journal of Psychological Medicine, 2016
Hyperprolactinemia is a common adverse effect of antipsychotic medication. Switching over to aripiprazole or adjunctive aripiprazole has been advocated for optimal management of antipsychotic-induced hyperprolactinemia.
Sam Padamadan Joseph
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Structural insight into small molecule action on Frizzleds

Nature Communications, 2020
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far.
Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Jana Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, Asuka Inoue, Carsten Hoffmann, Gunnar Schulte   +9 more
doaj   +1 more source

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Amaral, Anthony, Ashburner, Bauer, Beatrice Holt, Benedetto De Martino, Blair, Bond, Bouton, Buchel, Carmichael, Carter, Christian Büchel, Corcoran, Corcoran, Critchley, Davis, Deichmann, Deichmann, Delamater, Duvernoy, Ekman, Frankland, Friston, Friston, Gould, Guastella, Heresco-Levy, Hetem, Hofmann, Honey, Izquierdo, Ji, Kalisch, Kalisch, Kalisch, Kalisch, Karcz-Kubicha, Kim, Klodzinska, Kushner, LaBar, LaBar, Ledgerwood, Lee, Mao, Maren, Martin, McGaugh, Morris, Myers, Parwani, Pavlov, Penny, Phelps, Predrag Petrovic, Raffael Kalisch, Raymond J. Dolan, Ressler, Rodrigues, Rubin, Runyan, Scavio, Schafe, Seymour, Sheinin, Sotres-Bayon, Spielberger, Stefan Klöppel, Stewart, Takehara, Trevisan, van Berckel, Vervliet, Walker, Yang, Zhu, Zorawski   +77 more
core   +2 more sources

Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists [PDF]

British Journal of Pharmacology, 1988
The antinociceptive activity of a range of opioid agonists and agonist‐antagonist analgesics was determined in mice by use of the 55°C hot plate and abdominal constriction assays. Opioid agonists were approximately 10 times more effective in the abdominal constriction assay. The agonist‐antagonists produced analgesia only in the abdominal constriction
John S. Shaw, Karen M. Burns, Janet D. Rourke   +2 more
openaire   +3 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source