Results 81 to 90 of about 195,829 (332)

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, EarlyView.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals [PDF]

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Ana M. Soto, Anette Møller, Anita Oles-Karasko, Anna-Maria Andersson, Bigsby RM, Birgitte Gissel, Bodil Korsgaard, Carlos Sonnenschein, Eva Bonefeld Jørgensen, Farzad Pakdel, Helle Raun Andersen, Henrik Leffers, Herman Autrup, Jesper Bo Nielsen, John McLachlan, John P. Sumpter, Klotz DM, Knud L. Pedersen, Korach KS, Kuiper GGJM, Levin W, Lisette B. Christiansen, Marianne Barfoed, Nicola A. Beresford, Nicolas Olea, Niels Erik Skakkebœk, Philippe Grandjean, Pilar Perez, Poul Bjerregaard, Remy Le Guevel, René Hummel, Soto AM, Soto AM, Steven F. Arnold, Susan M. Thorpe   +34 more
core   +2 more sources

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation

Frontiers in Immunology
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity.
Burcu Temizoz, Burcu Temizoz, Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Tomoya Hayashi, Tomoya Hayashi, Kouji Kobiyama, Kouji Kobiyama, Kouji Kobiyama, Michelle Sue Jann Lee, Michelle Sue Jann Lee, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Atsushi Kumanogoh, Masahiro Yamamoto, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Cevayir Coban, Cevayir Coban, Cevayir Coban, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +30 more
doaj   +1 more source

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site [PDF]

, 2004
To study conformational transitions at the muscle nicotinic acetylcholine (ACh) receptor (nAChR), a rhodamine fluorophore was tethered to a Cys side chain introduced at the beta-19' position in the M2 region of the nAChR expressed in Xenopus oocytes ...
Auyeung, Vincent C., Bezanilla, Francisco, Chanda, Baron, Dahan, David S., Dibas, Mohammed I., Dougherty, Dennis A., Lester, Henry A., Petersson, E. James   +7 more
core  

Hooray for Hypoxia? [PDF]

, 2005
The mortality of critically ill patients rises steadily as the partial pressure of arterial oxygen falls below about 11 kPa (80 mm Hg). A new animal study in the May 2005 issue of PLoS Biology showing a potential benefit for hypoxia is thus a challenge ...
Bellingan, G
core   +4 more sources

Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Advanced Healthcare Materials, EarlyView.
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li, Jiahui Li, Hasan Al Faruque, Paul Shami, Birgit Knoechel, Jens Lohr, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček   +8 more
wiley   +1 more source

Serotonin system implication in L-DOPA-induced dyskinesia: from animal models to clinical investigations [PDF]

, 2014
In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA
CARTA, MANOLO, TRONCI, ELISABETTA
core   +1 more source

Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review

Advanced Healthcare Materials, EarlyView.
This article reviews fluorescent hydrogel systems for cancer detection, monitoring, and therapy. Mimicking the tumor microenvironment, these hydrogels enable real‐time imaging and targeted drug delivery. The review discusses design strategies, labeling techniques, and applications, highlighting challenges and future opportunities in cancer diagnostics ...
Elahe Masaeli, Seshasai Srinivasan, Amin Reza Rajabzadeh   +2 more
wiley   +1 more source

Buprenorphine – an attractive opioid with underutilized potential in treatment of chronic pain

Journal of Pain Research, 2015
Ish K Khanna, Sivaram PillarisettiNeuroPn Therapeutics, Alpharetta, GA, USAAbstract: Despite proven clinical utility, buprenorphine has not been used widely for the treatment of chronic pain.
Khanna IK, Pillarisetti S
doaj