The evolution of moment generating functions for the Wright Fisher model of population genetics
, 2014 We derive and apply a partial differential equation for the moment generating function of the Wright-Fisher model of population ...
Hofrichter, Julian +2 more
core +1 more source
An unsupervised deep learning approach to solving partial integro-differential equations [PDF]
, 2022 Weilong Fu, Ali Hirsa
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Exact solutions of some nonlinear evolution equations via the first integral method
Ain Shams Engineering Journal, 2013 The first integral method can be used to construct exact traveling wave solutions of nonlinear partial differential equations. In this work, we explore new application of this method to some special nonlinear partial differential equations.
N. Taghizadeh +2 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
An extension of A-stability to alternating direction implicit methods [PDF]
An alternating direction implicit (ADI) scheme was constructed by the method of approximate factorization. An A-stable linear multistep method (LMM) was used to integrate a model two-dimensional hyperbolic-parabolic partial differential equation ...
Beam, R. M., Warming, R. F.
core +1 more source
Review of: "New adaptative numerical algorithm for solving partial integro-differential equations" [PDF]
, 2023 Qiuyan Xu
openalex +1 more source
Geraghty-type theorems in modular metric spaces with an application to partial differential equation
, 2012 In this article, we prove some fixed point theorems of Geraghty-type concerning the existence and uniqueness of fixed points under the setting of modular metric spaces.
P. Chaipunya, Y. Je Cho, Poom Kumam
semanticscholar +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source