Results 71 to 80 of about 1,551,677 (306)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structured populations with distributed recruitment: from PDE to delay formulation

, 2016
In this work first we consider a physiologically structured population model with a distributed recruitment process. That is, our model allows newly recruited individuals to enter the population at all possible individual states, in principle.
Calsina, Àngel, Diekmann, Odo, Farkas, József Z.   +2 more
core   +1 more source

New solutions to a category of nonlinear PDEs

Frontiers in Physics
The nonlinear partial differential equations are not only used in many physical models, but also fundamentally applied in the field of nonlinear science. In order to solve certain nonlinear partial differential equation, the extended hyperbolic auxiliary
Bacui Li, Fuzhang Wang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hybrid deterministic stochastic systems with microscopic look-ahead dynamics [PDF]

, 2010
We study the impact of stochastic mechanisms on a coupled hybrid system consisting of a general advection-diffusion-reaction partial differential equation and a spatially distributed stochastic lattice noise model.
Katsoulakis, M. A., Majda, A. J., Sopasakis, A.   +2 more
core  

Exact solutions of the conformable fractional EW and MEW equations by a new generalized expansion method

Journal of Ocean Engineering and Science, 2020
In this paper, we used the generalized (G'/G)-expansion method to construct exact solutions for conformable fractional nonlinear partial differential equations.
Muhannad A. Shallal, Khalid K. Ali, Kamal R. Raslan, Hadi Rezazadeh, Ahmet Bekir   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Ulam-Hyers stability of a parabolic partial differential equation

Demonstratio Mathematica, 2019
The goal of this paper is to give an Ulam-Hyers stability result for a parabolic partial differential equation. Here we present two types of Ulam stability: Ulam-Hyers stability and generalized Ulam-Hyers-Rassias stability.
Marian Daniela, Ciplea Sorina Anamaria, Lungu Nicolaie   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

PDEs in Moving Time Dependent Domains

, 2013
In this work we study partial differential equations defined in a domain that moves in time according to the flow of a given ordinary differential equation, starting out of a given initial domain.
AJ Chorin, G Duvaut, H Amann, H Amann, OA Ladyzhenskaya, P Hartman   +5 more
core   +2 more sources