Results 61 to 70 of about 57,990 (260)

Inhomogeneous Schrödinger system with inverse square potential in three space dimensions

Journal of Inequalities and Applications
This work studies the inhomogeneous Schrödinger coupled system with inverse square potential i ∂ t u j + Δ u j − λ | x | 2 u j = ± | x | − τ ( ∑ k = 1 m a j k | u k | p ) | u j | p − 2 u j . $$ i\partial _{t} u_{j} +\Delta u_{j}-\frac{\lambda}{|x|^{2}}u_{
Salah Boulaaras, Radhia Ghanmi, Tarek Saanouni   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Method for Image Decontamination Based on Partial Differential Equation

MATEC Web of Conferences, 2015
This paper will introduce the method to apply partial differential equations for the decontamination processing of images. It will establish continuous partial differential mathematical models for image information and use specific solving methods to ...
Hou Junping
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Advancements in detecting, preventing, and mitigating DDoS attacks in cloud environments: A comprehensive systematic review of state-of-the-art approaches

Egyptian Informatics Journal
This comprehensive study examines cutting-edge strategies for combating Distributed Denial of Service (DDoS) attacks in cloud environments, addressing a critical gap in recent literature. Through a systematic review of the latest advancements, we propose
Mohamed Ouhssini, Karim Afdel, Mohamed Akouhar, Elhafed Agherrabi, Abdallah Abarda   +4 more
doaj   +1 more source

Partial differential equations with piecewise constant delay

International Journal of Mathematics and Mathematical Sciences, 1991
The influence of certain discontinuous delays on the behavior of solutions to partial differential equations is studied. In Section 2, the initial value problems (IVP) are discussed for differential equations with piecewise constant argument (EPCA) in ...
Joseph Wiener, Lokenath Debnath
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

DeepDefend: A comprehensive framework for DDoS attack detection and prevention in cloud computing

Journal of King Saud University: Computer and Information Sciences
DeepDefend is an advanced framework for real-time detection and prevention of DDoS attacks in cloud environments. It employs deep learning techniques, notably CNN-LSTM-Transformer networks, to predict network traffic entropy and detect potential attacks.
Mohamed Ouhssini, Karim Afdel, Elhafed Agherrabi, Mohamed Akouhar, Abdallah Abarda   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source