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On a linear system of differential equations
Вестник КазНУ. Серия математика, механика, информатика, 2019 The linear systems of partial differential equations of the first order with the identical main parts is considered. Аpplying the well-known relation between a normal system of ordinary differential equations and a linear system of partial differential
T. М. Aldibekov, M. M. Aldazharova
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FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Telematics and Informatics ReportsCloud computing environments face persistent threats from sophisticated Distributed Denial of Service (DDoS) attacks. Effective defense requires not only high accuracy but also real-time performance and transparent decision-making, a combination that ...
Mohamed Ouhssini +6 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Partial Differential Equations [PDF]
, 1988 In this chapter, procedures will be developed for classifying partial differential equations as elliptic, parabolic or hyperbolic. The different types of partial differential equations will be examined from both a mathematical and a physical viewpoint to indicate their key features and the flow categories for which they occur.
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Risks, 2020 In insurance mathematics, optimal control problems over an infinite time horizon arise when computing risk measures. An example of such a risk measure is the expected discounted future dividend payments.
Stefan Kremsner +2 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
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Partial differential equations in medical biophysics [PDF]
, 1982 A number of examples of collaborative research are outlined which show how mathematicians and medical biophysicists have contributed to a wider understanding of some problems in applied ...
Twizell, E H
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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