Results 61 to 70 of about 3,728,637 (232)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Non global solutions for non-radial coupled inhomogeneous non-linear Schrödinger systems

Boundary Value Problems
We establish finite-time blow-up of energy solutions to an inhomogeneous nonlinear coupled Schrödinger system under suitable conditions. The novelty of our approach lies in allowing non-radial initial data and removing the assumption of finite variance ...
Saleh Almuthaybiri, Radhia Ghanmi, Tarek Saanouni   +2 more
doaj   +1 more source

Genetic programming approaches for solving elliptic partial differential equations

, 2008
In this paper, we propose a technique based on genetic programming (GP) for meshfree solution of elliptic partial differential equations. We employ the least-squares collocation principle to define an appropriate objective function, which is optimized ...
Sobester, A., Keane, A.J., Nair, P.B., P.B. Nair, A.J. Keane, A. Sobester   +5 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Global solutions for bi-harmonic inhomogeneous non-linear Schrödinger equations in Lebesgue spaces

Journal of Inequalities and Applications
This paper studies the inhomogeneous bi-harmonic nonlinear Schrödinger equation i u ˙ + Δ 2 u ± | x | − τ | u | p − 1 u = 0 , $$ \mbox{i}\dot{u} +\Delta ^{2} u\pm |x|^{-\tau}|u|^{p-1}u=0, $$ where u : = u ( t , x ) : R × R N → C $u:=u(t,x):\mathbb{R ...
Radhia Ghanmi, Salah Boulaaras, Tarek Saanouni   +2 more
doaj   +1 more source

ON SINGULAR SOLUTIONS OF CLAIRAUT EQUATIONS IN THE THEORY OF ORDINARY DIFFERENTIAL AND PARTIAL DERIVATIVE EQUATIONS

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. There is no problem in finding a general solution to the ordinary differential Clairaut equation. The corresponding procedure is described in details in the theory of ordinary differential equations.
L. A. Zhidova
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Primal–Dual Interior Point Method for Complex–Variable Optimization Problems

International Journal of Applied Mathematics and Computer Science
In this paper, we propose a primal-dual interior-point method for solving convex optimization problems with complex variables, relying on a newly defined complex-valued kernel function.
Laouar Mounia, Brahimi Mahmoud, Ziadi Raouf, Saleh Mohammed A., Almaymuni Abdulgader Z., Alhalangy Abdalilah   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Inhomogeneous Schrödinger system with inverse square potential in three space dimensions

Journal of Inequalities and Applications
This work studies the inhomogeneous Schrödinger coupled system with inverse square potential i ∂ t u j + Δ u j − λ | x | 2 u j = ± | x | − τ ( ∑ k = 1 m a j k | u k | p ) | u j | p − 2 u j . $$ i\partial _{t} u_{j} +\Delta u_{j}-\frac{\lambda}{|x|^{2}}u_{
Salah Boulaaras, Radhia Ghanmi, Tarek Saanouni   +2 more
doaj   +1 more source