Results 61 to 70 of about 3,532,407 (279)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Expand-contract plasticity on the real line

Frontiers in Applied Mathematics and Statistics
The study deals with plastic and non-plastic sub-spaces A of the real-line ℝ with the usual Euclidean metric d. It investigates non-expansive bijections, proves properties of such maps, and demonstrates their relevance by hands of examples.
Dirk Langemann, Olesia Zavarzina
doaj   +1 more source

Superprocesses and Partial Differential Equations

The Annals of Probability, 1993
This is a survey of recent developments on measure-valued Markov processes including a number of the author's important contributions. This subject has its origins in the paper of \textit{S. Watanabe} [J. Math. Kyoto Univ. 8, 141-167 (1968; Zbl 0159.462)] in which a class of measure-valued branching processes was constructed based on a family of ...
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Renormalizing partial differential equations [PDF]

, 2008
In this review paper, we explain how to apply Renormalization Group ideas to the analysis of the long-time asymptotics of solutions of partial differential equations. We illustrate the method on several examples of nonlinear parabolic equations. We discuss many applications, including the stability of profiles and fronts in the Ginzburg-Landau equation,
Bricmont, J., Kupiainen, A.
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A method for constructing a complete bifurcation picture of a boundary value problem for nonlinear partial differential equations: application of the Kolmogorov-Arnold theorem [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
The purpose of this study is to develop a numerical method for bifurcation analysis of nonlinear partial differential equations, based on the reduction of partial differential equations to ordinary ones, using the Kolmogorov-Arnold theorem.
Gromov, Vasily Alexandrovich, Tomashchuk, Korney Kirillovich, Beschastnov, Yury Nikolaevich, Sidorenko, Artem Aleksandrovich, Kakurin, Vasily Vladimirovich   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Transparent DDoS defense by combining Kolmogorov–Arnold networks and XAI for real-time protection in cloud environments

Telematics and Informatics Reports
Cloud computing environments face persistent threats from sophisticated Distributed Denial of Service (DDoS) attacks. Effective defense requires not only high accuracy but also real-time performance and transparent decision-making, a combination that ...
Mohamed Ouhssini, Karim Afdel, Mohamed Akouhar, El hafed Agherrabi, Abdallah Abarda, Mohamed El Fatini, Hasna Mahmoud   +6 more
doaj   +1 more source