Results 91 to 100 of about 21,137 (209)

Enhancement of adult liver regeneration in mice through the hepsin-mediated epidermal growth factor receptor signaling pathway

Communications Biology
Given the widespread use of partial hepatectomy for treating various liver pathologies, understanding the mechanisms of liver regeneration is vital for enhancing liver resection and transplantation therapies. Here, we demonstrate the critical role of the
Yu-Fei Tsai, Mo-Chu Fang, Chien-Hung Chen, I-Shing Yu, Chia-Tung Shun, Mi-Hua Tao, Cheng-Pu Sun, Jean Lu, Jin-Chuan Sheu, Yu-Chen Hsu, Shu-Wha Lin   +10 more
doaj   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Glycyrrhizin attenuates endotoxin- induced acute liver injury after partial hepatectomy in rats

Brazilian Journal of Medical and Biological Research, 2007
Massive hepatectomy associated with infection induces liver dysfunction, or even multiple organ failure and death. Glycyrrhizin has been shown to exhibit anti-oxidant and anti-inflammatory activities.
B. Tang, H. Qiao, F. Meng, X. Sun
doaj  

Evaluating Nurses' Perspectives on the Acceptability and Practicality of Comfort Rounding for Personalised Nutritional and Mobility Care in Surgical Wards: A Mixed‐Methods Feasibility Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To evaluate nurses' perspectives on factors influencing the acceptability and practicality of comfort rounding, focussing on personalised nutritional and mobility care. Design Mixed‐methods feasibility study. Methods Focus group interviews with nurses were conducted before, during and at the end of the implementation period (2022–2023).
Femke Becking‐Verhaar, Fanny Pelzer, Harm Van Noort, Cariline Roosen, Yvonne Van Eijk‐Hustings, Marian De Van Der Schueren, Hester Vermeulen, Getty Huisman‐De Waal   +7 more
wiley   +1 more source

High Intrahepatic cccDNA in Resolved HBV Infection: Insights From Living Donor Liver Transplantation With Anti‐HBc‐Positive Grafts

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Aim In hepatitis B surface antigen (HBsAg)‐negative recipients with antibody to hepatitis B core antigen (anti‐HBc)‐positive liver grafts, hepatitis B virus (HBV) can be reactivated under post‐transplant immunosuppression. We recently reported a median intrahepatic covalently closed circular DNA (cccDNA) level of 238 copies/μg in HBsAg ...
Sung Kwan Bae, Nobuhisa Akamatsu, Akihiko Ichida, Yujiro Nishioka, Yoshinori Inagaki, Nozomi Miyake, Takeshi Takamoto, Yoshikuni Kawaguchi, Sumihito Tamura, Junichi Arita, Junichi Kaneko, Motoyuki Otsuka, Yasuhito Tanaka, Hiroshi Yotsuyanagi, Kyoji Moriya, Kiyoshi Hasegawa   +15 more
wiley   +1 more source

The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Liver‐related sarcopenia is a devastating systemic complication of chronic liver disease (CLD) driven by mechanisms extending beyond nutritional deficiency. However, the role of liver‐derived humoral factors remains unclear. We utilised a unique cohort of human skeletal muscle biopsies to test the hypothesis that serum conjugated ...
Motoh Iwasa, Akiko Eguchi, Motoyuki Kohjima, Teruo Miyazaki, Hiroshi Kitamura, Yuko Takami, Naoki Yamashita, Mina Tempaku, Kiyora Izuoka, Yoshinao Kobayashi, Yoshiyuki Takei, Akira Honda, Hayato Nakagawa, Tadashi Ikegami, Makoto Nakamuta, Jun Okabe, Aldo J. Montano‐Loza   +16 more
wiley   +1 more source

Anticipating postoperative complications in hepatobiliary surgery: procalcitonine as predictive factor

Frontiers in Surgery
Background and aimsFew studies have indicated that procalcitonin has a potential role in anticipating postoperative complications of hepatic surgery. Here, we focused on validating the relationship between posthepatectomy and serum procalcitonin as short-
Shouwen Zhao, Yuanyuan Song, Le Zhang, Sunan Shi, Jie Li, Yuping Ma, Yong Liao, Zhongguang Zhen   +7 more
doaj   +1 more source

Standardized Approach for Laparoscopic Hemispheric Liver Resection for Segments 7 and 8

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background We investigated whether the standardized “can‐opener method” surgical technique is an adequate surgical procedure for hemispheric hepatectomy in segments 7 and 8. Methods Forty‐two patients who underwent laparoscopic hemispheric liver resection for segments 7 and 8 using our standardized surgical technique were enrolled.
Ryoichi Miyamoto, Masahiro Shiihara, Mitsuru Watanabe, Jiro Shimazaki, Mitsugi Shimoda, Shuji Suzuki   +5 more
wiley   +1 more source

A Novel Technique of Overtube‐assisted Ultrathin Endoscopic Biliary Drainage Using Multi‐Hole Self‐Expandable Metal Stents: A Case Report

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Endoscopic retrograde cholangiopancreatography (ERCP) is the standard procedure for biliary drainage; however, access can be challenging in patients with altered anatomy or tumor‐related distortion. Endoscopic ultrasound‐guided biliary drainage (EUS‐BD) is a common alternative, yet it is not always feasible, particularly in patients with prior
Akinobu Koiwai, Morihisa Hirota, Kei Ishikawa, Chihiro Yunomura, Takuro Nakaya, Yuki Miyashita, Nana Inomata, Kennichi Satoh   +7 more
wiley   +1 more source

Protocol for establishing liver tumors via ultrasound-guided intrahepatic injection prior partial hepatic resection in a mouse model

STAR Protocols
Summary: We present a protocol to generate a liver tumor murine model utilizing orthotopic ultrasound-guided intrahepatic injections of tumor cells and a partial hepatectomy.
Shadin Ghabra, Rajiv Trehan, Francisco Rodriguez-Matos, Chi Ma, Tim F. Greten   +4 more
doaj   +1 more source