Results 11 to 20 of about 21,650 (215)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

LIVER RESTORATION FOLLOWING PARTIAL HEPATECTOMY AND CHOLECYSTILOBECTOMY IN DOG [PDF]

Assiut Veterinary Medical Journal, 1993
The present study was carried out on 28 clinically ste healthy adult dogs of both sexes. They were divided into four equal groups. Dogs of the first and third groups were subjected to 30% & 40% partial hepatectomy by the excision of the left lateral ...
M.T. NASSEF, M.A. ALI, A.S. SALEH, M.M. ABD EL-HAFEEZ   +3 more
doaj   +1 more source

Primary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue lymphoma treated by laparoscopic partial hepatectomy: a case report

Surgical Case Reports, 2023
Background Primary hepatic extranodal marginal zone B-cell mucosa-associated lymphoid tissue (MALT) lymphoma is very rare, so it is difficult to diagnose preoperatively. And there is no established treatment for hepatic MALT lymphoma.
Keisuke Okura, Satoru Seo, Hironori Shimizu, Hiroto Nishino, Tomoaki Yoh, Ken Fukumitsu, Takamichi Ishii, Koichiro Hata, Hironori Haga, Etsuro Hatano   +9 more
doaj   +1 more source

Pure Laparoscopic Hepatectomy Combined with a Pure Laparoscopic Pringle Maneuver in Patients with Severe Cirrhosis

Case Reports in Gastroenterology, 2015
Laparoscopic hepatectomy is a standard surgical procedure. However, it is difficult to perform in patients with severe cirrhosis because of fibrosis and a high risk of hemorrhage.
Shigehito Miyagi, Chikashi Nakanishi, Naoki Kawagishi, Takashi Kamei, Susumu Satomi, Noriaki Ohuchi   +5 more
doaj   +1 more source

CXC chemokines function as a rheostat for hepatocyte proliferation and liver regeneration. [PDF]

PLoS ONE, 2015
Our previous in vitro studies have demonstrated dose-dependent effects of CXCR2 ligands on hepatocyte cell death and proliferation. In the current study, we sought to determine if CXCR2 ligand concentration is responsible for the divergent effects of ...
Gregory C Wilson, Satoshi Kuboki, Christopher M Freeman, Hiroyuki Nojima, Rebecca M Schuster, Michael J Edwards, Alex B Lentsch   +6 more
doaj   +1 more source

Effect of angiotensin-converting enzyme inhibitor, lisinopril on morphological and biochemical aspects of fibrotic liver regeneration

The Saudi Journal of Gastroenterology, 2016
Background/Aims: Hepatic fibrosis results in defective liver regeneration following partial hepatectomy. Angiotensin converting enzyme (ACE) inhibitors can enhance liver regeneration and are also involved in the reduction of hepatic fibrosis. The present
Aysha Ambreen, Sarwat Jahan, Satwat Malik   +2 more
doaj   +1 more source

Cytochrome P450 enzymes activity in rat liver under conditions of toxic injury and partial hepatectomy [PDF]

The Ukrainian Biochemical Journal
The unique liver ability for reparative regeneration plays a decisive role in restoring its homeostatic potential. However, in certain clinical situations, in particular, due to the damage caused by toxicants of a medicinal origin, the regenerative ...
Н. P. Kopylchuk, I. M. Nykolaichuk, М. S. Ursatyi   +2 more
doaj   +1 more source

The ileum positively regulates hepatic regeneration in rats [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To test the hypothesis that liver regeneration after partial hepatectomy can be influenced by the ileum.METHODS:Eighteen Wistar rats were distributed into groups of six animals: 1 - ileum resection+ hepatectomy 2/3; 2 - hepatectomy 2/3, and 3 ...
Aldo Cunha Medeiros, Ana Clara Batista Azevedo, Jéssica Mayara de Figueiredo Oséas, Mariana Davim Ferreira Gomes, Fernanda Gurgel de Oliveira, Keyla Borges Ferreira Rocha, Ítalo Medeiros Azevedo, Amália Cínthia Meneses Rêgo, Marília Daniela Ferreira Carvalho   +8 more
doaj   +1 more source