Results 41 to 50 of about 25,796 (267)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Mid‐Lithospheric Discontinuity Detected Beneath 155 Ma Western Pacific Seafloor Using Sp Receiver Functions

Geophysical Research Letters
This study probes the lithosphere‐asthenosphere system beneath 155 Ma Pacific seafloor using teleseismic S‐to‐p receiver functions at the Pacific Lithosphere Anisotropy and Thickness Experiment project ocean‐bottom‐seismometers. Within the lithosphere, a
K.‐X. Chen, D. W. Forsyth, K. M. Fischer   +2 more
doaj   +1 more source

Mechanism of carbonate assimilation by intraplate basaltic magma and liquid immiscibility: example of Wangtian’e volcano (Changbaishan volcanic area, NE China)

Frontiers in Earth Science, 2023
The balance of CO2 during abundant basaltic magma production is an important factor of volcanic hazards and climate. In particular, this can be explored based on CO2-rich mantle-derived magmas or carbonate assimilation by basaltic melts.
Olga A. Andreeva, Elena Dubinina, Irina A. Andreeva, Vladimir V. Yarmolyuk, Andrey Bychkov, Anastassia Borisova, Jianqing Ji, Xin Zhou, Elena V. Kovalchuk, Sergey Y. Borisovsky, Alexey A. Averin   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Three‐dimensional electrical resistivity model of the hydrothermal system in Long Valley Caldera, California, from magnetotellurics

Geophysical Research Letters, 2016
Though shallow flow of hydrothermal fluids in Long Valley Caldera, California, has been well studied, neither the hydrothermal source reservoir nor heat source has been well characterized.
J. R. Peacock, M. T. Mangan, D. McPhee, P. E. Wannamaker   +3 more
doaj   +1 more source

Mapping the Lithosphere and Asthenosphere Beneath Alaska With Sp Converted Waves

Geochemistry, Geophysics, Geosystems, 2022
We obtained a 3D image of crust and mantle seismic velocity gradients beneath the state of Alaska using common‐conversion point (CCP) stacking of S‐to‐p converted body waves recorded by hundreds of stations from the NSF EarthScope Transportable Array and
Isabella Gama, Karen M. Fischer, Junlin Hua   +2 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

MECHANISM OF PARTIAL METAL MELT STRATIFICATION IN CAPILLARS [PDF]

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2013
Experimental results of diameter, inclination, angle and length effects on metal melt stratification rate are represented. These relationships determined experimentally were compared with relationships obtained on the basis of simple hydrodynamics ...
N.P. Ouglev
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluation of the contributions of possible sources to the leucosome of the diatexite of Socorro-Guaxupé Nappe, in the Alfenas Region, MG, Brazil

Brazilian Journal of Geology, 2019
The Socorro-Guaxupé Nappe crops out in southern Minas Gerais and it has an intermediate unit called Metaxite Unit, dominated by diatexites at its base, with large volumes of leucosome and schollen of stromatic garnet-biotite metatexite.
Lizeth Hernandez Tasco, Renato Moraes
doaj   +1 more source