Results 51 to 60 of about 27,193 (265)

Evaluation of the contributions of possible sources to the leucosome of the diatexite of Socorro-Guaxupé Nappe, in the Alfenas Region, MG, Brazil

Brazilian Journal of Geology, 2019
The Socorro-Guaxupé Nappe crops out in southern Minas Gerais and it has an intermediate unit called Metaxite Unit, dominated by diatexites at its base, with large volumes of leucosome and schollen of stromatic garnet-biotite metatexite.
Lizeth Hernandez Tasco, Renato Moraes
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mapping the Lithosphere and Asthenosphere Beneath Alaska With Sp Converted Waves

Geochemistry, Geophysics, Geosystems, 2022
We obtained a 3D image of crust and mantle seismic velocity gradients beneath the state of Alaska using common‐conversion point (CCP) stacking of S‐to‐p converted body waves recorded by hundreds of stations from the NSF EarthScope Transportable Array and
Isabella Gama, Karen M. Fischer, Junlin Hua   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

No Measurable Calcium Isotopic Fractionation During Crystallization of Kilauea Iki Lava Lake

Geochemistry, Geophysics, Geosystems, 2018
In order to investigate possible Ca isotopic fractionation during basaltic magma differentiation, we measured Ca isotopic compositions of lavas recovered from Kilauea Iki lava lake at Hawaii.
Hongming Zhang, Yang Wang, Yongsheng He, Fang‐Zhen Teng, Stein B. Jacobsen, Rosalind T. Helz, Bruce D. Marsh, Shichun Huang   +7 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Mid‐Lithospheric Discontinuity Detected Beneath 155 Ma Western Pacific Seafloor Using Sp Receiver Functions

Geophysical Research Letters
This study probes the lithosphere‐asthenosphere system beneath 155 Ma Pacific seafloor using teleseismic S‐to‐p receiver functions at the Pacific Lithosphere Anisotropy and Thickness Experiment project ocean‐bottom‐seismometers. Within the lithosphere, a
K.‐X. Chen, D. W. Forsyth, K. M. Fischer   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source