Results 41 to 50 of about 27,193 (265)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Three‐dimensional electrical resistivity model of the hydrothermal system in Long Valley Caldera, California, from magnetotellurics

Geophysical Research Letters, 2016
Though shallow flow of hydrothermal fluids in Long Valley Caldera, California, has been well studied, neither the hydrothermal source reservoir nor heat source has been well characterized.
J. R. Peacock, M. T. Mangan, D. McPhee, P. E. Wannamaker   +3 more
doaj   +1 more source

Derivation of intermediate to silicic magma from the basalt analyzed at the Vega 2 landing site, Venus. [PDF]

PLoS ONE, 2018
Geochemical modeling using the basalt composition analyzed at the Vega 2 landing site indicates that intermediate to silicic liquids can be generated by fractional crystallization and equilibrium partial melting. Fractional crystallization modeling using
J Gregory Shellnutt
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Dynamic Crust of Northern Afar and Adjacent Rift Margins: New Evidence From Receiver Function Analysis in Eritrea and Ethiopia

Geochemistry, Geophysics, Geosystems
Afar is undergoing the final stages of continental rifting and hosts the triple junction between the Red Sea, Gulf of Aden, and Main Ethiopian rifts.
M. Gauntlett, S. N. Stephenson, J.‐M. Kendall, C. Ogden, J. O. S. Hammond, T. Hudson, B. Goitom, G. Ogubazghi   +7 more
doaj   +1 more source

MECHANISM OF PARTIAL METAL MELT STRATIFICATION IN CAPILLARS [PDF]

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2013
Experimental results of diameter, inclination, angle and length effects on metal melt stratification rate are represented. These relationships determined experimentally were compared with relationships obtained on the basis of simple hydrodynamics ...
N.P. Ouglev
doaj  

Spontaneous small‐scale melt segregation in partial melts undergoing deformation [PDF]

Geophysical Research Letters, 1989
A partial melt undergoing large scale deformation is shown to be unstable with respect to small scale redistribution of melt, provided the shear viscosity of the matrix depends on melt fraction. In the physically realistic case where melt “softens” the matrix, melt migrates along the direction parallel to the axis of minimum compressive stress and ...
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Seismic Constraints on Temperature, Partial Melt, and Lithosphere‐Asthenosphere Dynamics in the Southwestern United States

Geochemistry, Geophysics, Geosystems
The southwestern United States hosts well‐documented and dramatic variations in topography, seismicity, heat flow, magmatism, and seismic velocity structure.
E. M. Golos, K. M. Fischer, Z. Eilon
doaj   +1 more source