Results 51 to 60 of about 25,796 (267)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

No Measurable Calcium Isotopic Fractionation During Crystallization of Kilauea Iki Lava Lake

Geochemistry, Geophysics, Geosystems, 2018
In order to investigate possible Ca isotopic fractionation during basaltic magma differentiation, we measured Ca isotopic compositions of lavas recovered from Kilauea Iki lava lake at Hawaii.
Hongming Zhang, Yang Wang, Yongsheng He, Fang‐Zhen Teng, Stein B. Jacobsen, Rosalind T. Helz, Bruce D. Marsh, Shichun Huang   +7 more
doaj   +1 more source

Formation of lower fast-spread oceanic crust: a structural and geochemical study of troctolites in the Hess Deep Rift (East Pacific Rise)

Progress in Earth and Planetary Science, 2023
Troctolites were recovered during Integrated Ocean Drilling Program Expedition 345 at the Hess Deep Rift, next to fast-spreading East Pacific Rise. These troctolites are divided into three groups based on textural differences: coarse-grained (1–10 mm in ...
Norikatsu Akizawa, Marguerite Godard, Benoît Ildefonse, Shoji Arai   +3 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Seismological Evidence of Multiple Crustal Magma Reservoirs Beneath Mt. Wrangell in Southcentral Alaska

Geophysical Research Letters
Recent studies have challenged the classical view of magma chambers as ephemeral, melt‐rich bodies confined to shallow depths beneath arc volcanoes at subduction zones.
Qili Andy Dai, Haiying Gao, Sahria Nayon, Zane Michael Cleghorn, Cong Li   +4 more
doaj   +1 more source

Olivine crystallographic control and anisotropic melt distribution in ultramafic partial melts [PDF]

Geophysical Research Letters, 1998
In the upper mantle, physical properties (permeability, electrical conductivity, and seismic velocity) are highly dependent on the melt geometry. Both flat and curved melt interfaces exist in olivine‐basalt partial melts. To further understand anisotropic wetting behavior of partial melting within the mantle, crystal orientation studies have been ...
Haemyeong Jung, Harve S. Waff
openaire   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Melt extraction from partially molten peridotites

Geochemistry, Geophysics, Geosystems, 2003
We measured the rate of melt extraction from partially molten olivine aggregates into a porous reservoir as a function of melt content (ϕ), melt viscosity, grain size, and pressure difference. Samples were prepared using mixtures of olivine and either lithium silicate, MORB glass, or albite glass to obtain a range in melt viscosities.
Jörg Renner, Karen Viskupic, Greg Hirth, Brian Evans   +3 more
openaire   +1 more source