Results 51 to 60 of about 1,449,845 (242)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Maximum Power Enhancement of Partially Shaded Photovoltaic Array by Advanced Total Cross-Tied Based Configuration

Journal of Engineering Technology and Applied Physics
Partial shading in solar photovoltaic arrays reduce the maximum power produced. Partial shading conditions in PV arrays can be caused by water, dust, tree shadows, bird-drops, nearby building, etc.
Kaung Khant Win, Yin Yin Mya
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An Enhanced Adaptive Perturb and Observe Technique for Efficient Maximum Power Point Tracking Under Partial Shading Conditions

Applied Sciences, 2020
In this paper, we propose enhanced adaptive step size Perturb and Observe (P&O) maximum power point tracking (MPPT) with properly organized comparison sequences which lead to achieving the actual maximum power point (MPP) effectively in the presence of ...
Altwallbah Neda Mahmod Mohammad, Mohd Amran Mohd Radzi, Norhafiz Azis, Suhaidi Shafie, Muhammad Ammirrul Atiqi Mohd Zainuri   +4 more
doaj   +1 more source

Numerical modeling, simulation and evaluation of conventional and hybrid photovoltaic modules interconnection configurations under partial shading conditions

EPJ Photovoltaics, 2022
Partial shading on solar photovoltaic (PV) arrays is a prevalent problem in photovoltaic systems that impair the performance of PV modules and is responsible for reduced power output as compared to that in standard irradiance conditions thereby resulting
Saeed Faisal, Tauqeer Haider Ali, Gelani Hasan Erteza, Yousuf Muhammad Hassan, Idrees Asad   +4 more
doaj   +1 more source

Modeling and detection of hot-spot in shaded photovoltaic cells [PDF]

, 2014
In this paper, we address the problem of modeling the thermal behavior of photovoltaic (PV) cells undergoing a hotspot condition. In case of shading, PV cells may experience a dramatic temperature increase, with consequent reduction of the provided power.
Giaffreda, Daniele, Giaffreda, D., Metra, Cecilia, Omana, Martin, Rossi D., Omana M., Omana, M., Giaffreda D., Metra C., Metra, C., OMANA, MARTIN EUGENIO, Rossi, D., Rossi, Daniele   +12 more
core   +1 more source

Optimal PV array configurations for partial shading conditions [PDF]

, 2023
Increasing the effectiveness of photovoltaic (PV) power generation systems is a major barrier to their widespread use. Partial shading conditions (PSCs), which are caused by nearby objects like trees, buildings, and clouds, reduce the energy produced by ...
R. Kareem, Parween, Jasim, Husniyah, Sameer Algburi, H. Hasan, Fattah, Husniyah Jasim, Parween R. Kareem, Fattah H. Hasan, Algburi, Sameer   +7 more
core   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source