Results 91 to 100 of about 333,295 (341)

Quantitative Model‐Informed Dose Selection for a Milvexian Phase III Study in Patients With Atrial Fibrillation

Clinical Pharmacology &Therapeutics, EarlyView.
Milvexian, an activated factor XI inhibitor, is being evaluated in the LIBREXIA phase III program for the prevention of thrombotic events, including in patients with atrial fibrillation (LIBREXIA AF). To guide the selection of a phase III dose regimen for LIBREXIA AF, two main approaches were used: (1) population pharmacokinetics and exposure–response ...
Wangda Zhou, Emily Bozenhardt, Gregory E. Alexander, Matthew L. Zierhut, Samira Merali, Antoinette Ajavon‐Hartmann, Peter Zannikos, Hyunmoon Back, EunYoung Suh, Navin Goyal, Mahesh N. Samtani, Alexei N. Plotnikov, Chandni Valiathan   +12 more
wiley   +1 more source

Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and Art Status [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: HIV infection is known to cause coagulation abnormalities by various mechanism, especially during its late course. Aim: The objective of this study is to analyse platelet count, prothrombin time and activated partial thromboplastin time
R Thulasi Raman, D Manimaran, Praveen Rachakatla, K Bharathi, Tameem Afroz, Radha Sagar   +5 more
doaj   +1 more source

Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]

, 2012
Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Barnett, A. H., Cooke, Matthew, Hawkey, P. M., Hong, Tan, Jones, Alan, Linhartova, Lucie, Melody, Teresa, Patel, Jaimin M., Perkins, Gavin D., Smith, F. Gao, Snaith, Catherine, Thickett, David R.   +11 more
core   +3 more sources

Noncontact Monitoring and AI‐Driven Stroke Prediction: National Center for Neurological Disorders‐Based Approach Using Smart Beds

Health Care Science, EarlyView.
The burden of stroke is extremely heavy. Current prehospital tools are not suitable for identifying stroke while a patient is asleep. This study successfully identified strokes by combining three types of easily accessible temporal and static features in hospitals.
Lan Lan, Jia‐Wei Luo, Rui Li, Ling Guan, Xin Wang, Jin Yin, Yi‐Long Wang   +6 more
wiley   +1 more source

Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis

Biomedicines
Background: Subacute thyroiditis (SAT) is characterized by profound inflammation and fluctuations in thyroid hormones which may affect the hemostasis balance.
Jelena Vekic, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Neda Milinkovic, Sanja Gluscevic, Serpil Ciftel, Filiz Mercantepe   +6 more
doaj   +1 more source

Variations in activated partial thromboplastin time and prothrombin time in individuals of A, B, AB, and O blood groups

Iraqi Journal of Hematology, 2018
Background: Differences in blood group have been associated with predisposition to some diseases. Activated partial thromboplastin time (APTT) measures the efficiency of the intrinsic and common coagulation pathways, whereas prothrombin time (PT) test ...
Chizoba Okechukwu Okeke, Uru Star Okoro, Abiodun Babatunde   +2 more
doaj   +1 more source

Effect of Haemodialysis on Mean Prothrombin Time and Activated Partial Thromboplastin Time in Patients of End Stage Renal Disease

Journal of Rawalpindi Medical College, 2015
Background: To determine mean prothrombin time and activated partial thromboplastin time in patients of end stage renal disease having normal baseline coagulation parameters after hemodialysis.
Attika Khalid
doaj  

Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients

International Journal of Cancer, EarlyView.
What's New? Immune checkpoint inhibitors (ICIs) are effective against various cancers, but as more patients receive these therapies, more immune‐related adverse events (irAEs) emerge. Recent studies have suggested that ICIs are associated with an increase in pulmonary artery diameter and the ratio between pulmonary artery diameter and aortic diameter ...
Yao Xu, Qiuhong Zhang, Jie Gao, Shiyuan Yao, Chan Tian, Tuo He, Ming Zhang, Hu Shan, Jie Shi, Bo Yuan, Lei Wang, Xia Yang   +11 more
wiley   +1 more source

Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened.
Lucia Rugeri, Yelena Fruchou, Caroline Brodbeck, Marianne Bastien, Amandine Lioux, Giulia Gouy, Marion Cortet, Gil Dubernard, Yesim Dargaud   +8 more
wiley   +1 more source

Application of Point‐of‐Care Testing for Coagulation Tests: A Comparison of Consistency and Interference With a Fully Automatic Coagulation Analysis System

iLABMED, EarlyView.
We collected a total of 551 plasma samples and covered prothrombin time/international normalized ratio (PT/INR), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB). Assess the correlation, consistency, and conformity of the mechanical‐based coagulation POCT system compared with the fully automated coagulation ...
Weiqi Cui, Wei Xu, Yongbing Fan, Xu Wang, Jibao Zhu, Linlin Qu   +5 more
wiley   +1 more source