Results 101 to 110 of about 353,583 (326)

Anti‐PF4 disorders: Pathogenesis, diagnosis and treatment

British Journal of Haematology, EarlyView.
Anti‐platelet factor 4 (PF4) disorders include heparin‐induced thrombocytopenia (HIT) and vaccine‐induced immune thrombocytopenia and thrombosis (VITT)/VITT‐like disorders. The formation of immunoglobulin G (IgG)/PF4 immune complexes facilitates uncontrolled activation of platelets, neutrophils and monocytes via IgG‐mediated Fcγ receptor binding.
Megan V. Preece, Devi V. Pathak, Mike Laffan, Deepa J. Arachchillage   +3 more
wiley   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Comparison of Anti–Factor Xa Heparin Activity and Activated Partial Thromboplastin Time in 2,773 Plasma Samples From Unfractionated Heparin–Treated Patients [PDF]

, 1997
Terry K. Rosborough
openalex   +1 more source

Acute hepatitis and haemolysis associated with doxycycline and rifampin administration in two weanling foals

Equine Veterinary Education, EarlyView.
Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock, D. Wong, T. Hall, B. Sponseller, J. Howard, K. Frerichs, A. Bianco, R. Ruby   +7 more
wiley   +1 more source

Systemic lupus erythematosus caused acquired hemophilia B without evidence of factor IX inhibitors

Rheumatology &Autoimmunity, EarlyView.
Lifang Wang, Yan Ding, Lei Wang, Lianjie Shi   +3 more
wiley   +1 more source

Integration of machine learning and viscoelastic testing to improve survival prediction in horses experiencing acute abdominal pain at a veterinary teaching hospital

Equine Veterinary Journal, EarlyView.
Abstract Background Viscoelastic coagulation testing (VCT) identifies subclinical disruption of coagulation homeostasis and may improve prognostication, particularly for patients with severe systemic inflammation or shock. Machine learning (ML) algorithms may capture complex relationships between clinical variables better than linear regression (GLM ...
Brandi M. Macleod, Pamela A. Wilkins, Annette M. McCoy, Rebecca C. Bishop   +3 more
wiley   +1 more source

Preparation of lyophilized partial thromboplastin time reagent composed of synthetic phospholipids: usefulness for monitoring heparin therapy [PDF]

, 1997
A M van den Besselaar, J. Neuteboom, J Meeuwisse-Braun, R M Bertina   +3 more
openalex   +1 more source

Evaluation of One‐Stage Assays for the Monitoring of Recombinant Human Factor IX Padua Activity After Etranacogene Dezaparvovec Gene Therapy

Haemophilia, EarlyView.
ABSTRACT Introduction Accurate and reproducible measures of factor activity are required to guide clinical decision‐making following gene therapy for haemophilia B (HB). Highly significant discrepancies have been observed in measurements of various factor IX (FIX) concentrates that carry molecular modifications to extend their half‐life, arguing for ...
Jan Astermark, Wolfgang Miesbach, Michiel Coppens, Sander Gielen, Jaap Twisk, Ricardo Dolmetsch, Stephanie Verweij, Paul E. Monahan, Bruce M. Ewenstein, Silpa Nuthalapati, Nick Galante, Guy Young, the HOPE‐B study investigators   +12 more
wiley   +1 more source

Artifactual Prolongation of the Activated Partial Thromboplastin Time Associated With Hemoconcentration in Dogs [PDF]

, 1995
Susan R. O'Brien, Teresa S. Sellers, Dennis J. Meyer   +2 more
openalex   +1 more source

Profiling of Anti‐FVIII Antibodies in Acquired Haemophilia A: ‘Insights into Domain Specificity, Isotype Variability, and Clinical Correlations’

Haemophilia, EarlyView.
ABSTRACT Introduction Acquired haemophilia A (AHA) is a rare autoimmune disorder caused by autoantibodies against coagulation factor VIII (FVIII), resulting in significant bleeding risks. Aim To characterize the anti‐FVIII antibody profile in AHA patients by assessing isotypes, subclasses, and correlations with key clinical parameters.
Ann‐Cristin Berkemeier, Isabell Matuschek, Katrin Hartlieb, Thilo Albert, Natascha Marquardt, Johannes Oldenburg, Behnaz Pezeshkpoor   +6 more
wiley   +1 more source