Results 231 to 240 of about 55,546 (301)

MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
1. PNH patients lack the complement regulatory proteins CD55 and CD59, triggering excessive activation of the terminal complement pathway and a prothrombotic state. 2. MUC4 mutation is an independent thrombotic risk factor in PNH. 3. Mutation/down‐regulation of MUC4 promotes the abnormal deposition of excessively activated terminal complement ...
Yingying Chen, Mengting Che, Chaomeng Wang, Qiaoyi Bronte Zhang, Weixin Chen, Hui Liu, Chunyan Liu, Guang Sheng Ling, Rong Fu   +8 more
wiley   +1 more source

Managing Treatment‐Emergent Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CAR‐T Cell Therapy: A Case‐Based Review of the use of Emapalumab

Hematological Oncology, Volume 44, Issue 1, January 2026.
ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapies have revolutionized the treatment of hematological malignancies, achieving high response rates in patients with relapsed or refractory disease. Despite these benefits, CAR‐T cell therapies are associated with unique toxicities, including cytokine release syndrome (CRS), immune effector cell ...
Livia Donzelli, Veronica Zullino, Giovanni Fernando Torelli, Maria Stefania De Propris, Mario Piazzolla, Franco Ruberto, Maurizio Martelli, Alice Di Rocco   +7 more
wiley   +1 more source

Interfacility Collaboration for Hemophilia Care in Japan: A Retrospective Database Study Using a Japanese Healthcare Claims Database

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims In Japan, about 6000 patients with hemophilia A (PwHA) are separately cared for at ~1000 clinics or hospitals. Interfacility collaboration (IFC) between hemophilia treatment centers and “satellite” medical facilities located closer to patients is necessary to eliminate care disparities.
Ei Kinai, Masako Yamaguchi, Akira Shirahata   +2 more
wiley   +1 more source

Hodgkin Lymphoma With Liver Involvement (Diagnostic, Therapeutic Difficulties, and Literature Review): A Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims In classical Hodgkin lymphoma liver involvement occurs in 5%–8%, ranging from mild dysfunction to acute liver failure. Recognition and treatment of advanced cases are challenging due to rapid progression and limited use of therapies. Methods We analyzed the data of 250 Hodgkin lymphoma patients; 9 had liver involvement, one
Fanni Borics, Roxana Szabó, Sándor Barna, Judit Bedekovics, Boglárka Brúgós, Árpád Illés, Zsófia Miltényi   +6 more
wiley   +1 more source

Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding

International Journal of Gynecology &Obstetrics, Volume 172, Issue 1, Page 250-254, January 2026.
Abstract Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened.
Lucia Rugeri, Yelena Fruchou, Caroline Brodbeck, Marianne Bastien, Amandine Lioux, Giulia Gouy, Marion Cortet, Gil Dubernard, Yesim Dargaud   +8 more
wiley   +1 more source

A Case of Acquired Factor V Deficiency in a Hemodialysis Patient: A Case Report With Literature Review

IJU Case Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Acquired factor V (FV) deficiency is a rare bleeding disorder requiring careful management, especially in hemodialysis (HD) patients who regularly receive anticoagulants. We present a case of recurrent acquired FV deficiency in a dialysis patient.
Akihiko Sugino, Yoshiyuki Miyazawa, Shugo Harashima, Yusaku Shimizu, Mikiya Kajita, Yuri Miyazawa, Yoshiyuki Ogawa, Hiroshi Handa, Yoshitaka Sekine, Kazuhiro Suzuki   +9 more
wiley   +1 more source

Remarkable Prolongation of Irreversible APTT and Non‐Significant Hemorrhage: A Rare High Titer of FVIII Inhibitor Case Report and Literature Review

Journal of Clinical Laboratory Analysis, Volume 40, Issue 2, January 2026.
Patient with a bladder cancer history presented was diagnosed with Acquired hemophilia A (AHA) according to imaging findings and laboratory tests. The parameters returned to normal after treatment of methylprednisolone and cyclophosphamide. With the recurrence of AHA, the patient was finally confirmed to have liver metastases.
Ke‐Han Zhang, Song‐Song Lu, Pei‐Liang Gao, Xue‐Ying Fu, Gui‐Ying Dong   +4 more
wiley   +1 more source

Prognostic Factors for Complications Following Ultrasound‐Guided Percutaneous Kidney Biopsy: A 7‐Year Retrospective Study

Journal of Clinical Ultrasound, Volume 54, Issue 1, Page 23-32, January 2026.
Complications were common but mostly minor following ultrasound‐guided percutaneous kidney biopsy. Older age, obesity, and smoking were independently associated with a reduced risk of complications, including hematoma. These findings highlight the overall safety of the procedure and support individualized risk assessment based on patient ...
Sehyun Jung, Seunghye Lee, Hyejin Jeon, Hani Jang, Se‐Ho Chang, Hyun‐Jung Kim   +5 more
wiley   +1 more source

Intra‐articular and intra‐osseous expanded adipose‐derived stromal cell injections for knee osteoarthritis‐related bone marrow lesions yield promising outcomes: Preliminary results in 16 athletes

Journal of Experimental Orthopaedics, Volume 13, Issue 1, January 2026.
Abstract Purpose To explore the results of a fluoroscopic‐guided intra‐osseous (IO) and intra‐articular (IA) injection of expanded adipose‐derived stromal cells (ASCs) in athletes with bone marrow lesions (BML) associated with knee osteoarthritis (OA).
Miguel A. Khoury, Emmanuel T. Papakostas, Theodorakys Marín Fermín, Montassar Tabben, Karim Chamari, Lorena Levi, Khaled Alkhelaifi, Pieter D'Hooghe   +7 more
wiley   +1 more source

A Novel PCK1 Gene Variant Associated With Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Two Siblings With Different Clinical Presentations

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Cytosolic phosphoenolpyruvate carboxykinase (PEPCK‐C) deficiency is a rare autosomal recessive gluconeogenesis disorder caused by variants in the PCK1 gene. Clinically, PEPCK‐C deficiency is characterized by recurrent episodes of fasting‐induced hypoglycemia, liver dysfunction, and seizures, with the first hypoglycemic episode typically ...
Lauma Vasiļevska, Ieva Puķīte, Madara Auzenbaha, Dmitrijs Rots, Ieva Grīnfelde, Andžela Lazdāne, Sebastian Schulz‐Jürgensen   +6 more
wiley   +1 more source